http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12740
Arachidonic acid induces specific membrane permeability increase in heart mitochondria (Articolo in rivista)
- Type
- Label
- Arachidonic acid induces specific membrane permeability increase in heart mitochondria (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Di Paola M.; Zaccagnino P.; Oliveros-Celis C.; Lorusso M. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Biomembranes and Bioenergetics, CNR, Bari, Italy; Department of Medical Biochemistry, Biology and Physics, University of Bari, Bari, Italy. (literal)
- Titolo
- Arachidonic acid induces specific membrane permeability increase in heart mitochondria (literal)
- Abstract
- Micromolar concentrations of arachidonic acid cause
in Ca2+ loaded heart mitochondria matrix swelling and Ca2+ release.
These effects appear to be unrelated to the classical membrane
permeability transition (MPT), as they are CsA
insensitive, membrane potential independent and can also be activated
by Sr2+. Atractyloside potentiated and ATP inhibited the
arachidonic acid induced swelling. These observations suggest
that the ATP/ADP translocator (ANT) may be involved in the
AA induced, CsA insensitive membrane permeability increase.
Under the same experimental conditions used for heart mitochondria,
arachidonic acid induced the classical CsA sensitive,
ADP inhibitable MPT in liver mitochondria. (literal)
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