Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Vacca R.A 1, Moro L 1, Caraccio G 2, Guerrieri F 2, Marra E 1, Greco M 1 (2003)
  Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties
  in Endocrinology (Philadelphia)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vacca R.A 1, Moro L 1, Caraccio G 2, Guerrieri F 2, Marra E 1, Greco M 1 (literal)

Pagina inizio

• 3783 (literal)

Pagina fine

• 3788 (literal)

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• 144 (literal)

Rivista

• Endocrinology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Si dimostra per la prima volta il ruolo dell'ormone tiroideo T3 nel modulare le proprietà di permeabilità di membrana dei mitocondri. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1-Institute of Biomembranes and Bioenergetics, CNR, Bari, Italy 2-Department of Medical Biochemistry and Biology, University of Bari, Italy (literal)

Titolo

• Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties (literal)

Abstract

• We have investigated the effect of thyroid hormone on the mitochondrial membrane permeability properties in a hypothyroid rat model. The role played by calcium in affecting these properties has been also examined. Cyclosporin A-sensitive mitochondrial calcium efflux, swelling, and external release of matrix proteins are events that occur normally during the permeability transition process induced by calcium loading of mitochondria. We demonstrate that these events are impaired in mitochondria isolated from the liver of hypothyroid rats, even in the presence of high calcium content. However, after thyroid hormone administration to hypothyroid rats, the mitochondrial permeability transition process in response to calcium loading is restored. Consequently, mitochondrial calcium efflux, swelling, and release of matrix proteins, like glutamate dehydrogenase, malate dehydrogenase, and aspartate aminotransferase occur. These effects are abrogated by the concomitant administration of cyclosporin A. The results of the present study suggest that hypothyroidism may be a potential source of adverse effects in patients receiving cyclosporin A. (literal)

Prodotto di

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR

• ROSA ANNA VACCA (Persona)
• LOREDANA MORO (Unità di personale interno)
• ERSILIA MARRA (Unità di personale interno)
• MARGHERITA GRECO (Persona)

Insieme di parole chiave

• Parole chiave di "Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR di

• LOREDANA MORO (Unità di personale interno)
• ROSA ANNA VACCA (Persona)
• MARGHERITA GRECO (Persona)
• ERSILIA MARRA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Endocrinology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties" (Insieme di parole chiave)