http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12674
Rat hindlimb unloading: Soleus and Extensor Digitorum Longus histochemistry, mitochondrial DNA content and mitochondrial DNA deletions (Articolo in rivista)
- Type
- Label
- Rat hindlimb unloading: Soleus and Extensor Digitorum Longus histochemistry, mitochondrial DNA content and mitochondrial DNA deletions (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Pesce V., Cormio A., Fracasso F., Lezza A.M.S., Cantatore P., Gadaleta M.N. (2002)
Rat hindlimb unloading: Soleus and Extensor Digitorum Longus histochemistry, mitochondrial DNA content and mitochondrial DNA deletions
in Bioscience reports
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pesce V., Cormio A., Fracasso F., Lezza A.M.S., Cantatore P., Gadaleta M.N. (literal)
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- Rivista
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- ISI Web of Science (WOS) (literal)
- Titolo
- Rat hindlimb unloading: Soleus and Extensor Digitorum Longus histochemistry, mitochondrial DNA content and mitochondrial DNA deletions (literal)
- Abstract
- Mitochondrial phenotypic alterations, mitochondrial DNA content and
mitochondrial DNA deletions in a slow, Soleus, and a fast, Extensor
Digitorum Longus, skeletal muscle of 3- and 15-month-old hindlimb suspended
rats have been studied. Cytochrome c oxidase-negative fibers appeared after
unloading in all examined animals and their percentage increased with
increasing unloading time. After 14 days of suspension the mitochondrial
DNA content did not change in 3-month-old but decreased significantly in
15-month-old rats. Soleus was much more affected by unloading than Extensor
Digitorum Longus. The mitochondrial DNA deletion of 4834 bp as well as
other mtDNA deletions, researched with Long Distance-PCR, were absent in
both studied muscles before and after unloading. (literal)
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