Bronchial epithelial damage after a half-marathon in nonasthmatic amateur runners. (Articolo in rivista)

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  • Bronchial epithelial damage after a half-marathon in nonasthmatic amateur runners. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1152/ajplung.00053.2010 (literal)
Alternative label
  • Laura Chimenti,1; Giuseppe Morici,2,3; Alessandra Paternò,1; Roberta Santagata,1; Anna Bonanno,3; Mirella Profita,3; Loredana Riccobono,3; Vincenzo Bellia,1; and Maria R. Bonsignore1,3 (2010)
    Bronchial epithelial damage after a half-marathon in nonasthmatic amateur runners.
    in American journal of physiology. Lung cellular and molecular physiology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Laura Chimenti,1; Giuseppe Morici,2,3; Alessandra Paternò,1; Roberta Santagata,1; Anna Bonanno,3; Mirella Profita,3; Loredana Riccobono,3; Vincenzo Bellia,1; and Maria R. Bonsignore1,3 (literal)
Pagina inizio
  • L857 (literal)
Pagina fine
  • L862 (literal)
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  • 298 (literal)
Rivista
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  • Epub 2010 Apr 2. PubMed PMID: 20363849. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Department Biomedico Di Medicina Interna & Specialistica, Section of Pneumology, and 2 Department of Experimental Medicine, University of Palermo, and 3 Institute of Biomedicine and Molecular Immunology, National Research Council, Palermo, Italy (literal)
Titolo
  • Bronchial epithelial damage after a half-marathon in nonasthmatic amateur runners. (literal)
Abstract
  • High neutrophil counts in induced sputum have been found in nonasthmatic amateur runners at rest and after a marathon, but the pathogenesis of airway neutrophilia in athletes is still poorly understood. Bronchial epithelial damage may occur during intense exercise, as suggested by investigations conducted in endurance-trained mice and competitive human athletes studied under resting conditions. To gain further information on airway changes acutely induced by exercise, airway cell composition, apoptosis, IL-8 concentration in induced sputum, and serum CC-16 level were measured in 15 male amateur runners at rest (baseline) and shortly after a half-marathon. Different from results obtained after a marathon, neutrophil absolute counts were unchanged, whereas bronchial epithelial cell absolute counts and their apoptosis increased significantly (P < 0.01). IL-8 in induced sputum supernatants almost doubled postrace compared with baseline (P < 0.01) and correlated positively with bronchial epithelial cell absolute counts (R2 = 0.373, P < 0.01). Serum CC-16 significantly increased after all races (P < 0.01). These data show mild bronchial epithelial cell injury acutely induced by intense endurance exercise in humans, extending to large airways the data obtained in peripheral airways of endurance-trained mice. Therefore, neutrophil influx into the airways of athletes may be secondary to bronchial epithelial damage associated with intense exercise. (literal)
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