Emerging MEK inhibitors. (Articolo in rivista)

Type
Label
  • Emerging MEK inhibitors. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1517/14728210903282760 (literal)
Alternative label
  • McCubrey JA, Steelman LS, Abrams SL, Chappell WH, Russo S, Ove R, Milella M, Tafuri A, Lunghi P, Bonati A, Stivala F, Nicoletti F, Libra M, Martelli AM, Montalto G, Cervello M. (2010)
    Emerging MEK inhibitors.
    in Expert opinion on investigational drugs
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • McCubrey JA, Steelman LS, Abrams SL, Chappell WH, Russo S, Ove R, Milella M, Tafuri A, Lunghi P, Bonati A, Stivala F, Nicoletti F, Libra M, Martelli AM, Montalto G, Cervello M. (literal)
Pagina inizio
  • 203 (literal)
Pagina fine
  • 223 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • PubMed PMID: 20151845. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Brody School of Medicine at East Carolina University, Department of Microbiology & Immunology, 600 Moye Boulevard, Greenville, NC 27858, USA Brody School of Medicine at East Carolina University, Leo Jenkins Cancer Center, Department of Radiation Oncology, 600 Moye Blvd, Greenville, 27834, USA Regina Elena Cancer Center, Via Elio Chianesi n.53, Rome 00144, Italy University of Rome, La Sapienza, Department of Hematology-Oncology, Via Benevento 6, Rome 99161, Italy University of Parma, Department of Clinical Sciences, Via Gramsci n.14, Parma 43100, Italy University Hospital of Parma, Unit of Hematology and Bone-Marrow Transplantation, Via Gramsi n.14, Parma 43100, Italy University of Catania, Department of Biological Sciences, Via Androne 83, Catania 95124, Italy University of Bologna, Department of Human Anatomical Sciences, Via Imerio 48, Bologna, Italy University of Palermo, Department of Clinical Medicine and Emerging Pathologies, 141 Via del Vespro, Palermo 90127, Italy Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia, Molecolare 'Alberto Monroy\", Via Ugo La Malfa 153, Palermo 90146, Italy (literal)
Titolo
  • Emerging MEK inhibitors. (literal)
Abstract
  • Importance of the field: The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signaling molecules. Integral components of this pathway such as Ras and B-Raf are also activated by mutation. The Ras/Raf/MEK/ERK pathway has profound effects on proliferative, apoptotic and differentiation pathways. This pathway can often be effectively silenced by MEK inhibitors. Areas covered by this review: This review will discuss targeting of MEK which could lead to novel methods to control abnormal proliferation which arises in cancer and other proliferative diseases. This review will cover the scientific literature from 1980-present. What the readerwill gain: By reading this reviewthe reader will understand the important roles that genetics play in the response of patients toMEK inhibitors, the potential of combining MEK inhibitors with other types of therapy, the prevention of cellular aging and the development of cancer stem cells. Take home message: Targeting MEK has been shown to be effective in suppressing many important pathways involved in cell growth and the prevention of apoptosis. MEK inhibitors have many potential therapeutic uses in the suppression of cancer, proliferative diseases and aging. (literal)
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