Genomic profiling of â-amyloid induced apoptosis in cortical neurons (Abstract/Poster in convegno)

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  • Genomic profiling of â-amyloid induced apoptosis in cortical neurons (Abstract/Poster in convegno) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
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  • S. Paratore1, R. Parenti2, A. Torrisi1, A. Copani3, F. Cicirata2, *S. Cavallaro1; (2006)
    Genomic profiling of â-amyloid induced apoptosis in cortical neurons
    in Congresso annuale della Società Americana di Neuroscienze 2006, Atlanta, GA, USA
    (literal)
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  • S. Paratore1, R. Parenti2, A. Torrisi1, A. Copani3, F. Cicirata2, *S. Cavallaro1; (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • In vitro and in vivo studies have shown that -amyloid peptide induces neuronal apoptotic cell death. To explore the molecular basis underlying the apoptotic machinery following -amyloid treatment, we analyzed gene expression profiles of cultured rat cortical neurons treated for 24 and 48 hours with synthetic -amyloid peptide. From the 8740 genes interrogated by oligonucleotide microarray analysis, 241 genes were found differentially expressed and segregated into distinct clusters. Functional clustering based on gene ontologies showed coordinated expression of genes with common biological functions and metabolic pathways. The comparison with genes differentially expressed in apoptotic cerebellar granule neurons following serum and potassium deprivation indicates the existence of common regulatory mechanisms underlying apoptotic cell death. Our results offer a genomic view of the changes that accompany -amyloid induced neurodegeneration. (literal)
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  • 1Institute of Neurological Sciences, Italian National Research Council, Catania, ITALY, 2Department of Physiological Sciences, University of Catania, Catania, ITALY, 3Department of Pharmaceutical Sciences, University of Catania, Catania, ITALY. (literal)
Titolo
  • Genomic profiling of â-amyloid induced apoptosis in cortical neurons (literal)
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