Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors. (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Alternative label

• Sarrazin N; Di Blasi F; Roullot-Lacarrière V; Rougé-Pont F; Le Roux A; Costet P; Revest JM; Piazza PV. Istituto di Biomedicina e di Immunologia Molecolare "Alberto Monroy" Consiglio Nazionale delle Ricerche Via Ugo La Malfa 153 90146 Palermo Italy Transgenesis Laboratory, Universite´ de Bordeaux, Bordeaux, France (2009)
  Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors.
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sarrazin N; Di Blasi F; Roullot-Lacarrière V; Rougé-Pont F; Le Roux A; Costet P; Revest JM; Piazza PV. Istituto di Biomedicina e di Immunologia Molecolare \"Alberto Monroy\" Consiglio Nazionale delle Ricerche Via Ugo La Malfa 153 90146 Palermo Italy Transgenesis Laboratory, Universite´ de Bordeaux, Bordeaux, France (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 4 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• PubMed PMID: 19888328; PubMed Central PMCID: PMC2765620. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Pathophysiology of Addiction group, Neurocenter Magendie, INSERM U862, Bordeaux, France (literal)

Titolo

• Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors. (literal)

Abstract

• The Glucocorticoid Receptor (GR) is a transcription factor ubiquitously expressed in the brain. Activation of brain GRs by high levels of glucocorticoid (GC) hormones modifies a large variety of physiological and pathological-related behaviors. Unfortunately the specific cellular targets of GR-mediated behavioral effects of GC are still largely unknown. To address this issue, we generated a mutated form of the GR called DeltaGR. DeltaGR is a constitutively transcriptionally active form of the GR that is localized in the nuclei and activates transcription without binding to glucocorticoids. Using the tetracycline-regulated system (Tet-OFF), we developed an inducible transgenic approach that allows the expression of the DeltaGR in specific brain areas. We focused our study on a mouse line that expressed DeltaGR almost selectively in the glutamatergic neurons of the dentate gyrus (DG) of the hippocampus. This restricted expression of the DeltaGR increased anxiety-related behaviors without affecting other behaviors that could indirectly influence performance in anxiety-related tests. This behavioral phenotype was also associated with an up-regulation of the MAPK signaling pathway and Egr-1 protein in the DG. These findings identify glutamatergic neurons in the DG as one of the cellular substrate of stress-related pathologies. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Caratterizzazione di una nuova isoforma di p65, proteina del complesso NF-kB, e suo ruolo nel controllo dell’infiammazione. Utilizzo di lieviti autoctoni per la produzione di vini (SV.P17.008.005) (Modulo)

Autore CNR

• FRANCESCO DI BLASI (Unità di personale interno)

Incoming links:

Autore CNR di

• FRANCESCO DI BLASI (Unità di personale interno)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Caratterizzazione di una nuova isoforma di p65, proteina del complesso NF-kB, e suo ruolo nel controllo dell’infiammazione. Utilizzo di lieviti autoctoni per la produzione di vini (SV.P17.008.005) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)