Transforming Growth Factor ’1 T29c Gene Polymorphism And Hypertension: Relationship With Cardiovascular And Renal Damage (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Transforming Growth Factor ’1 T29c Gene Polymorphism And Hypertension: Relationship With Cardiovascular And Renal Damage (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Argano C, Duro G, Corrao S, Di Chiara T, Nuzzo D, Colomba D, Scaglione R, Licata G . (2008)
  Transforming Growth Factor ’1 T29c Gene Polymorphism And Hypertension: Relationship With Cardiovascular And Renal Damage
  in Blood pressure
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Argano C, Duro G, Corrao S, Di Chiara T, Nuzzo D, Colomba D, Scaglione R, Licata G . (literal)

Pagina inizio

• 220 (literal)

Pagina fine

• 226 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 17 (literal)

Rivista

• Blood pressure (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• duro giovanni IBIM CNR palermo (literal)

Titolo

• Transforming Growth Factor ’1 T29c Gene Polymorphism And Hypertension: Relationship With Cardiovascular And Renal Damage (literal)

Abstract

• Distribution of T29C TGF beta 1 gene polymorphism was analysed in 260 hypertensive and 134 normotensive subjects. Circulating TGF beta 1 and procollagen type III levels, microalbuminuria, left ventricular geometry and function were evaluated in all the hypertensives subgrouped according to T29C TGF beta 1 gene polymorphism. Circulating TGF beta 1 by ELISA technique, procollagen type III by a specific radioimmunoassay, microalbuminuria by radioimmunoassay, left ventricular geometry and function by echocardiography were determined. All groups were comparable for gender, age and sex. Regarding T29C TGF beta 1 gene polymorphism, prevalence of TC or CC genotypes was significantly (p < 0.05) higher in hypertensives than normotensives. TC and CC hypertensives were characterized by a higher prevalence of subjects with microalbuminuria (p < 0.001 TC vs TT; p < 0.05 CC vs TT), left ventricular hypertrophy (p < 0.01 TC and CC vs TT), and by increased levels of procollagen type III (p < 0.05 TC and CC vs TT). TC hypertensives were also characterized by a significant increase (p < 0.05) of LVM and LVM/h(2.7) and of urinary albumin excretion (p < 0.05) values than those detectable in TT hypertensives. Our data suggest that T29C TGF beta 1 gene polymorphism was associated to clinical characteristics suitable to recognize hypertensives with a higher severity of hypertension. (literal)

Prodotto di

• Studio enzimatico e genetico di malattie metaboliche. (SV.P17.008.006) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Diffusione e deposizione delle componenti biologiche dell'atmosfera, effetto sulla salute e studio della biodiversità. (SV.P17.008.007) (Modulo)

Autore CNR

• Domenico Nuzzo (Unità di personale esterno)
• GIOVANNI DURO (Persona)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Diffusione e deposizione delle componenti biologiche dell'atmosfera, effetto sulla salute e studio della biodiversità. (SV.P17.008.007) (Modulo)
• Studio enzimatico e genetico di malattie metaboliche. (SV.P17.008.006) (Modulo)

Autore CNR di

• GIOVANNI DURO (Persona)
• Domenico Nuzzo (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Blood pressure (Rivista)