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Factors Responsible For Differences Between Asymptomatic Subjects And Patients Presenting An Ige Sensitization To Allergens. A Galen Project. (Articolo in rivista)

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Factors Responsible For Differences Between Asymptomatic Subjects And Patients Presenting An Ige Sensitization To Allergens. A Galen Project. (Articolo in rivista) (literal)

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J. Bousquet(1); J. M. Anto(2);C. Bachert(3); P. J. Bousquet(1); P. Colombo(4); R. Crameri(5); M. Daeron(6);W. Fokkens(7); B. Leynaert(8); C. Lahoz(9);M. Maurer(10); G. Passalacqua(11);R. Valenta(12); M. van Hage(13);R. Van Ree(14) (2006)
Factors Responsible For Differences Between Asymptomatic Subjects And Patients Presenting An Ige Sensitization To Allergens. A Galen Project.
in Allergy (Cph.); Blackwell Publishing, Oxford (Regno Unito)
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J. Bousquet(1); J. M. Anto(2);C. Bachert(3); P. J. Bousquet(1); P. Colombo(4); R. Crameri(5); M. Daeron(6);W. Fokkens(7); B. Leynaert(8); C. Lahoz(9);M. Maurer(10); G. Passalacqua(11);R. Valenta(12); M. van Hage(13);R. Van Ree(14) (literal)

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Attività editoriale derivante dalla partecipazione del sottoscritto all'interno del progetto: Study of asymptomatic subjects and subjects with sensitization to Parietaria and birch pollen, a pilot study\" del W.P. 2.6 del GA2LEN, finanziato dal 6° Programma Quadro della Comunità Europea. Network di Eccellenza: Global Allergy and Asthma European Network (GA2LEN) n. FOO-CT-2004-506378 VI PROGRAMMA QUADRO (literal)

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1)Service des Maladies Respiratoires, University Hospital, Montpellier, France; 2)Respiratory and Environmental Health Research Unit, Institut Municipal d'Investigacio Medica, Barcelona, Spain; 3)ENT-Department, University Hospital Ghent, Ghent, Belgium; 4)Istituto di Biomedicina e di Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Palermo, Italy; 5)Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland; 6)Unitè d'Allergologie Moleculaire et Cellulaire, Institut Pasteur, Paris, France; 7)Department of Otorhinolaryngology, University of Amsterdam, Amsterdam, the Netherlands; 8)INSERM U700, Paris, France; 9)Fundacion Jimenez Diaz, Immunology Department, Universidad Aut_noma de Madrid, Madrid, Spain; 10Klinik fur Dermatologie, Venerologie und Allergologie, Charitè - Universit_tsmedizin Berlin, Germany; 11)Allergy & Respiratory Diseases Department of Internal Medicine Padiglione Maragliano, Genoa, Italy; 12)Division of Immunopathology, Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Austria; 13)Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute and University Hospital, Stockholm, Sweden; 14)Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands (literal)

Titolo

Factors Responsible For Differences Between Asymptomatic Subjects And Patients Presenting An Ige Sensitization To Allergens. A Galen Project. (literal)

Abstract

The synthesis of allergen-specific IgE is required for the development of allergic diseases including allergic rhinitis and allergic asthma (patients), but many individuals with allergen-specific IgE do not develop symptoms (asymptomatic subjects). Differences may exist between asymptomatic subjects and patients. Whether the presence of allergen-specific IgE translates into clinical allergy most likely depends on a complex interplay of multiple factors. These include a family history of atopy, the levels of total serum IgE and, allergen-specific IgE or IgG, epitope-specificity of IgE and their degree of polyclonality (mono- vs polysensitized), as yet unidentified serum factors, the balance of T regulatory cells (Treg) and Th1/Th2 cells, the polymorphisms of the high affinity receptor for IgE (FceRI) and other factors regulating the activation of FceRI-bearing cells. Asymptomatic subjects may be more often monosensitized than patients who may be more often polysensitized. There are many unanswered important questions that need to be addressed in order to better understand how IgE sensitization translates into clinical allergy. The assessment of differences between the asymptomatic and symptomatic groups of subjects represent one of the scientific programs of Global Allergy and Asthma European Network funded by the European Union and the hypotheses underlying these differences are presented in this paper. (literal)

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