Reticulocytes in untreated Obstructive Sleep Apnoea (Articolo in rivista)

Type
Label
  • Reticulocytes in untreated Obstructive Sleep Apnoea (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Marrone O; Salvaggio A; Gioia M; Bonanno A; Profita M; Riccobono L; Zito A; Insalaco G; Bonsignore MR. (2008)
    Reticulocytes in untreated Obstructive Sleep Apnoea
    in Monaldi archives for chest disease; Pime, Pavia (Italia)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Marrone O; Salvaggio A; Gioia M; Bonanno A; Profita M; Riccobono L; Zito A; Insalaco G; Bonsignore MR. (literal)
Pagina inizio
  • 107 (literal)
Pagina fine
  • 113 (literal)
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  • http://archest.fsm.it/pne/index.html (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 69 (literal)
Rivista
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  • 3 (literal)
Note
  • PubMe (literal)
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  • National Research Council of Italy, Institute of Biomedicine and Molecular Immunology \"A. Monroy\", Palermo, Italy; DIMPEFINU, University of Palermo, Palermo, Italy; V. Cervello Hospital, Laboratory of Clinical Pathology, Palermo, Italy (literal)
Titolo
  • Reticulocytes in untreated Obstructive Sleep Apnoea (literal)
Abstract
  • Reticulocytes in untreated Obstructive Sleep Apnoea. O. Marrone, A. Salvaggio, M. Gioia, A. Bonanno, M. Profita, L. Riccobono, A. Zito, G. Insalaco, M.R. Bonsignore. Background and Aim. The short, repetitive hypoxaemic episodes observed in obstructive sleep apnoea (OSA) may determine small augmentations in mature red blood cells. It is unknown whether they affect reticulocyte release. This study explored whether the number and degree of maturation of circulating reticulocytes may be altered in OSA, possibly through the effect of erythropoietin. Methods. Fifty male adult patients with suspected OSA, normoxic during wakefulness, were studied. After nocturnal polysomnography, a blood sample was withdrawn for blood cells count, erythropoietin, iron and transferrin determination. Reticulocyte concentration and degree of immaturity [high (H), medium (M), or low (L)] were also determined. Immature reticulocyte fraction (IRF) was calculated as (M+H) percentage of reticulocytes. Results. A wide range of OSA severity was found [apnoea/ hypopnoea index (AHI): 44.3±30.4, range 0.3-105; sleep time spent at oxyhaemoglobin saturation <90%: 18.1±22.2%, range 0-81%]. Both reticulocyte count and IRF slightly exceeded the normal range. Patients with a reticulocyte concentration >2% had higher EPO levels (p<0.05), but not worse nocturnal desaturations, than those with values <2%. By contrast, subjects with IRF <15% showed worse desaturations (p<0.05), but similar EPO concentrations, when compared to subjects whose IRF was <10%. At univariate analysis, reticulocyte count correlated to erythropoietin, while IRF to transferrin saturation, BMI and OSA severity. At multiple regression, only lowest nocturnal oxygen saturation remained a significant contributor to IRF (r2 0.223, p<0.05). Conclusions. This data suggests that hypoxaemia due to OSA could influence the release of immature reticulocytes, but this effect is not mediated by erythropoietin. (literal)
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