Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1183/09031936.06.00057205 (literal)

Alternative label

• F. Guddo*; A.M. Vignola#,+; M. Saetta¶; S. Baraldo¶; L. Siena#; E. Balestro¶; R. Zuin¶; A. Papi+; P. Maestrelli§; L.M. Fabbri?; G. Bonsignore# and G. Turato¶ (2006)
  Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis
  in The European respiratory journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• F. Guddo*; A.M. Vignola#,+; M. Saetta¶; S. Baraldo¶; L. Siena#; E. Balestro¶; R. Zuin¶; A. Papi+; P. Maestrelli§; L.M. Fabbri?; G. Bonsignore# and G. Turato¶ (literal)

Pagina inizio

• 957 (literal)

Pagina fine

• 963 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 27 (literal)

Rivista

• ?The ?European respiratory journal (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• *Pathology Unit, V. Cervello Hospital, #Institute of Lung Pathophysiology, National Research Council, Palermo, ¶Dept of Cardiothoracic and Vascular Sciences, Section of Respiratory Diseases §Dept of Environmental Medicine and Public Health, University of Padova, Padova, +Dept of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Ferrara, Ferrara, ?Dept of Oncology and Hematology, Section of Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy. (literal)

Titolo

• Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis (literal)

Abstract

• The aim of the study was to investigate the expression of basic fibroblast growth factor (bFGF) and its receptor, fibroblast growth factor receptor (FGFR)-1, in the central airways of smokers with chronic bronchitis. The lobar bronchi from 17 subjects undergoing thoracotomy for solitary nodules were examined. All had a history of cigarette smoking, nine had symptoms of chronic bronchitis and airflow limitation, and eight were asymptomatic with normal lung function. Using immunohistochemical methods, bFGF and FGFR-1 expression in the total airway wall and the different airway compartments, i.e. bronchial glands, submucosal vessels and smooth muscle, was quantified. Moreover, to investigate the role of bFGF in angiogenesis, the number of submucosal vessels was quantified. Smokers with chronic bronchitis had an increased bFGF expression in the total airway wall compared with asymptomatic smokers, which was mainly due to bFGF upregulation in bronchial glands. By contrast, the expression of FGFR-1 and the number of submucosal vessels was similar in the two groups of subjects examined. In conclusion, smokers with chronic bronchitis have an increased expression of basic fibroblast growth factor in the central airways, which is mainly due to an increased expression in bronchial glands, suggesting the involvement of this growth factor in the pathogenesis of chronic bronchitis. (literal)

Prodotto di

• Immunopatologia e Farmacologia Clinica e Sperimentale nelle malattie respiratorie (ME.P01.014.005) (Modulo)
• Modelli ex vivo/in vitro per lo studio dell'immunopatologia e della farmacologia nelle pneumopatie (ME.P01.014.007) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Immunopatologia e Farmacologia nelle Pneumopatie: studi dei meccanismi molecolari in vivo e in modelli in vitro (ME.P01.014.006) (Modulo)

Autore CNR

• GIOVANNI BONSIGNORE (Unità di personale interno)
• LIBORIA SIENA (Persona)

Insieme di parole chiave

• Parole chiave di "Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Immunopatologia e Farmacologia nelle Pneumopatie: studi dei meccanismi molecolari in vivo e in modelli in vitro (ME.P01.014.006) (Modulo)
• Immunopatologia e Farmacologia Clinica e Sperimentale nelle malattie respiratorie (ME.P01.014.005) (Modulo)
• Modelli ex vivo/in vitro per lo studio dell'immunopatologia e della farmacologia nelle pneumopatie (ME.P01.014.007) (Modulo)

Autore CNR di

• GIOVANNI BONSIGNORE (Unità di personale interno)
• LIBORIA SIENA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?European respiratory journal (Rivista)

Insieme di parole chiave di

• Parole chiave di "Upregulation of basic fibroblast growth factor in smokers with chronic bronchitis" (Insieme di parole chiave)