Analysis of candidate genes in celiac disease: a tool to identify life-threatening associated genesi (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Analysis of candidate genes in celiac disease: a tool to identify life-threatening associated genesi (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Nuzzo D; Cataldo F; Scola L; Forte GI; Crivello A; Giacalone A; Accomando S; Barbieri R; Candore G; Caruso C; Lio D (2006)
  Analysis of candidate genes in celiac disease: a tool to identify life-threatening associated genesi
  in Rejuvenation research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Nuzzo D; Cataldo F; Scola L; Forte GI; Crivello A; Giacalone A; Accomando S; Barbieri R; Candore G; Caruso C; Lio D (literal)

Pagina inizio

• 153 (literal)

Pagina fine

• 156 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• Rejuvenation research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ibim cnr (literal)

Titolo

• Analysis of candidate genes in celiac disease: a tool to identify life-threatening associated genesi (literal)

Abstract

• The authors have recently reported that celiac patients show a proinflammatory cytokine genetic profile characterized by the contemporaneous presence of both the tumour necrosis factor- ?-308A and the interferon-? ?874T allele-positive genotypes. The same alleles are considered risk factors for aging associated disease, whereas an anti-inflammatory cytokine genotype profile might be associated with an extended life expectancy. This paper reports data on the 1249-1250InsACAA/Non-Ins transforming growth factor (TGF)-?2, a multifunctional anti-inflammatory cytokine, polymorphism distribution in 88 celiac disease (CD) patients, 99 age- and sex-matched controls, and 28 ?95-year-old healthy subjects living in western Sicily. These data demonstrate that genotype frequencies of CD patients are not different from that of age-matched and ?95-year-old healthy control subjects. These data might suggest that TGF-?2 polymorphism is not involved in the complex genotypes associated with successful or unsuccessful aging. In addition, one can speculate that the genotype profile associated with CD susceptibility might be detrimental for longevity, and studies of this CD genetic asset might point to a candidate gene for antiaging strategies. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• Domenico Nuzzo (Persona)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR di

• Domenico Nuzzo (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Rejuvenation research (Rivista)