Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1183/09031936.05.00144304 (literal)

Alternative label

• J.P. Lamb*,#; A. James*,¶; N. Carroll*; L. Siena+; J. Elliot* and A.M. Vignola++,§ (2005)
  Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma
  in European respiratory journal (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• J.P. Lamb*,#; A. James*,¶; N. Carroll*; L. Siena+; J. Elliot* and A.M. Vignola++,§ (literal)

Pagina inizio

• 265 (literal)

Pagina fine

• 270 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 26 (literal)

Rivista

• European respiratory journal (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• *Dept of Pulmonary Physiology, Sir Charles Gairdner Hospital, and #Dept of Physiology, and ¶School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia. +Instituto di Biomedicinia e Moleculare, and §Cattedra di Malattie Fisiopatologica, Palermo, Italy. (literal)

Titolo

• Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma (literal)

Abstract

• Effector memory T-cells (CD45RO+) may provide pro-inflammatory signals that contribute to the persistent airway inflammation that is characteristic of asthma, and reduced apoptosis of these cells may prolong their effects. The present authors compared apoptosis of CD45RO+ T-cells in the inner airway wall in nonfatal asthma (n57), fatal asthma (n57) and control (n58) cases. Apoptotic cells were identified using both the terminal deoxynucleotidyl transferase dNTP nick end-labelling (TUNEL) technique and cell morphology. The percentage of CD45RO+ T-cells that were apoptotic was significantly greater in control cases compared with nonfatal and fatal cases of asthma, respectively, in small (42¡19, 16¡9, 7¡6%), medium (40¡12, 15¡11, 12¡8%) and large airways (42¡15, 23¡18, 18¡12%). The reduction in the percentage of apoptotic CD45RO+ cells in the cases of asthma was observed in both blood vessels and the interstitium in large airways. In conclusion, these data suggest that reduced apoptosis may prolong the active life of effector memory T-cells in the airways. It is possible that survival signals may be received before cells migrate into the interstitium of the inner airway wall. KEYWORDS: Airways inflammation, apoptosis, asthma, (literal)

Prodotto di

• Modelli ex vivo/in vitro per lo studio dell'immunopatologia e della farmacologia nelle pneumopatie (ME.P01.014.007) (Modulo)
• Immunopatologia e Farmacologia Clinica e Sperimentale nelle malattie respiratorie (ME.P01.014.005) (Modulo)
• Immunopatologia e Farmacologia nelle Pneumopatie: studi dei meccanismi molecolari in vivo e in modelli in vitro (ME.P01.014.006) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• LIBORIA SIENA (Persona)

Insieme di parole chiave

• Parole chiave di "Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Immunopatologia e Farmacologia nelle Pneumopatie: studi dei meccanismi molecolari in vivo e in modelli in vitro (ME.P01.014.006) (Modulo)
• Immunopatologia e Farmacologia Clinica e Sperimentale nelle malattie respiratorie (ME.P01.014.005) (Modulo)
• Modelli ex vivo/in vitro per lo studio dell'immunopatologia e della farmacologia nelle pneumopatie (ME.P01.014.007) (Modulo)

Autore CNR di

• LIBORIA SIENA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European respiratory journal (Rivista)

Insieme di parole chiave di

• Parole chiave di "Reduced apoptosis of memory T-cells in the inner airway wall of mild and severe asthma" (Insieme di parole chiave)