Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected mice. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected mice. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.tube.2004.09.006 (literal)

Alternative label

• Reljic R; Di Sano C; Crawford C; Dieli F; Challacombe S; Ivanyi J. (2005)
  Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected mice.
  in Tuberculosis (Edinb.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Reljic R; Di Sano C; Crawford C; Dieli F; Challacombe S; Ivanyi J. (literal)

Pagina inizio

• 81 (literal)

Pagina fine

• 88 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 85 (literal)

Rivista

• Tuberculosis (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1-2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department for Oral Medicine and Pathology, Guy's Campus of King's College, London, UK Department of Biopathology, University of Palermo, Palermo, Italy (literal)

Titolo

• Time course of mycobacterial infection of dendritic cells in the lungs of intranasally infected mice. (literal)

Abstract

• Setting: Dendritic cells (DC) could regulate between the protective and pathogenic immune responses following tuberculous infection. In this paper we investigated if their early infection in the lungs represents a plausible alternative to cross-priming with mycobacterial antigens acquired from infected macrophages. Objective: To determine the extent and time course of infection of lung DCs following intranasal inoculation of BALB/c mice with green fluorescent protein (GFP) tagged Bacillus Calmette-Guerin (BCG). Results: A fraction of GFP-BCG infected lung cells were classified as monocytic DCs with the CD11c(+)IA(+)33D1(+)CD8a(-) phenotype. These cells represented 5-18% of the total GFP(+) cells, the bulk of which were macrophages. The infected DCs could be separated by cell size into two fractions with similar cell surface staining properties during the 2-72 h period after infection. An unexpected difference was observed for the time course of infection between DCs and macrophages: DC infection peaked at 48h followed by decline at 72h, while the proportion of infected macrophages remained steady during the same period. Conclusion: The presented results are direct evidence that monocytic DCs are recruited to the lungs and take up live bacilli within 48 h of intranasal infection with GFP-BCG. This finding is pertinent for the regulation of pulmonary and systemic immune responses and possibly for the dissemination of mycobacterial infection by DCs. (C) (literal)

Prodotto di

• Immunoregolazione TBC e Trapianti (ME.P04.003.001) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• FRANCESCO DIELI (Unità di personale esterno)
• CATERINA DI SANO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Immunoregolazione TBC e Trapianti (ME.P04.003.001) (Modulo)

Autore CNR di

• CATERINA DI SANO (Unità di personale interno)
• FRANCESCO DIELI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Tuberculosis (Rivista)