The MAPK pathway and Egr-1 are molmecular substrate of stress-related effents of glucocorticoids (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The MAPK pathway and Egr-1 are molmecular substrate of stress-related effents of glucocorticoids (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/nn1441 (literal)

Alternative label

• Revest. JM, Di Blasi F., Kitchener P, Rouge-Pont F, Turiault M, Tronche F, Piazza PV (2005)
  The MAPK pathway and Egr-1 are molmecular substrate of stress-related effents of glucocorticoids
  in Nature neuroscience (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Revest. JM, Di Blasi F., Kitchener P, Rouge-Pont F, Turiault M, Tronche F, Piazza PV (literal)

Pagina inizio

• 664 (literal)

Pagina fine

• 672 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 8 (literal)

Rivista

• Nature neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• INSERM U588, Laboratoire de Physiopathologie du Comportement, Bordeaux Institute for Neurosciences, University Victor Segalen-Bordeaux 2, Domaine de Carreire, 146 Rue Léo Saignat, 33077 Bordeaux Cedex, France. CNRS UMR 5106 Laboratoire de Neurosciences Cognitives Avenue des Facultés 33405 Talence, France Istituto di Biomedicina e di Immunologia Molecolare \"Alberto Monroy\" Consiglio Nazionale delle Ricerche Via Ugo La Malfa 153 90146 Palermo Italy. CNRS FRE2401, Molecular Genetics, Neurophysiology and Behavior, Institute of Biology, Collège de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 5, France (literal)

Titolo

• The MAPK pathway and Egr-1 are molmecular substrate of stress-related effents of glucocorticoids (literal)

Abstract

• Many of the behavioral consequences of stress are mediated by the activation of the glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore the molecular mechanisms of these effects, we combined in vivo and in vitro approaches. We analyzed mice carrying a brain-specific mutation (GRNesCre) in the glucocorticoid receptor gene (GR, also called Nr3c1) and cell lines that either express endogenous glucocorticoid receptor or carry a constitutively active form of the receptor (?GR) that can be transiently induced. In the hippocampus of the mutant mice after stress, as well as in the cell lines, activation of glucocorticoid receptors greatly increased the expression and enzymatic activity of proteins in the MAPK signaling pathway and led to an increase in the levels of both Egr-1 mRNA and protein. In parallel, inhibition of the MAPK pathway within the hippocampus abolished the increase in contextual fear conditioning induced by glucocorticoids. The present results provide a molecular mechanism for the stress-related effects of glucocorticoids on fear memories. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• (SV.P12.003) Individuazione, recupero e conservazione della biodiversità dei lieviti siciliani e loro catalogazione territoriale. (SV.P17.003.001) (Modulo)

Autore CNR

• FRANCESCO DI BLASI (Unità di personale interno)

Incoming links:

Autore CNR di

• FRANCESCO DI BLASI (Unità di personale interno)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• (SV.P12.003) Individuazione, recupero e conservazione della biodiversità dei lieviti siciliani e loro catalogazione territoriale. (SV.P17.003.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature neuroscience (Rivista)