Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and hnRNPD (JKTBP-1) proteins reciprocally regulate the transcription activity by physical interaction with BERF1/ZBP-89 Factor (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and hnRNPD (JKTBP-1) proteins reciprocally regulate the transcription activity by physical interaction with BERF1/ZBP-89 Factor (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1074/jbc.M403160200 (literal)

Alternative label

• Boopathi E, Lenka N, Prabu SK, Fang JK, Wilkinson F, Atchison M, Giallongo A, Avadhani. NG (2004)
  Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and hnRNPD (JKTBP-1) proteins reciprocally regulate the transcription activity by physical interaction with BERF1/ZBP-89 Factor
  in The Journal of biological chemistry (Print); American Society Of Biochemistry And Molecular Biology Inc. (ASBMB), Rockville (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Boopathi E, Lenka N, Prabu SK, Fang JK, Wilkinson F, Atchison M, Giallongo A, Avadhani. NG (literal)

Pagina inizio

• 35242 (literal)

Pagina fine

• 35254 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 279 (literal)

Rivista

• ?The ?Journal of biological chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 34 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA CNR, Ist Biomed & Immunol Mol, I-90146 Palermo, Italy (literal)

Titolo

• Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and hnRNPD (JKTBP-1) proteins reciprocally regulate the transcription activity by physical interaction with BERF1/ZBP-89 Factor (literal)

Abstract

• : A transcription suppressor element (sequence -481 to -320) containing a G-rich motif (designated GTG) and a newly identified CAT-rich motif (designated CATR) was previously shown to modulate expression of the mouse cytochrome c oxidase Vb gene during myogenesis. Here, we show that the GTG element is critical for transcription activation in both undifferentiated and differentiated myocytes. Mutations of the CATR motif abolished transcription repression in myoblasts while limiting transcription activation in differentiated myotubes, suggesting contrasting functional attributes of this DNA motif at different stages of myogenesis. Results show that the activity of the transcription suppressor motif is modulated by an orchestrated interplay between ubiquitous transcription factors: ZBP-89, YY-1, and a member of the heterogeneous nuclear ribonucleoprotein D-like protein (also known as JKTBP1) family. In undifferentiated muscle cells, GTG motif-bound ZBP-89 physically and functionally interacted with CATR motif-bound YY-1 to mediate transcription repression. In differentiated myotubes, heterogeneous nuclear ribonucleoprotein D-like protein/JKTBP1 bound to the CATR motif exclusive of YY-1 and interacted with ZBP-89 in attenuating repressor activity, leading to transcription activation. Our results show a novel mechanism of protein factor switching in transcription regulation of the cytochrome c oxidase Vb gene during myogenesis. (literal)

Editore

• American Society Of Biochemistry And Molecular Biology Inc. (ASBMB) (Editore)

Prodotto di

• Controllo trascrizionale e post-trascrizionale nello sviluppo, nel differenziamento cellulare e nella trasduzione del segnale (SV.P15.002.001) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• AGATA GIALLONGO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and hnRNPD (JKTBP-1) proteins reciprocally regulate the transcription activity by physical interaction with BERF1/ZBP-89 Factor" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Controllo trascrizionale e post-trascrizionale nello sviluppo, nel differenziamento cellulare e nella trasduzione del segnale (SV.P15.002.001) (Modulo)

Autore CNR di

• AGATA GIALLONGO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?Journal of biological chemistry (Rivista)

Editore di

• American Society Of Biochemistry And Molecular Biology Inc. (ASBMB) (Editore)

Insieme di parole chiave di

• Parole chiave di "Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and hnRNPD (JKTBP-1) proteins reciprocally regulate the transcription activity by physical interaction with BERF1/ZBP-89 Factor" (Insieme di parole chiave)