Effect of age and asthma duration upon elastase and alpha1-antitrypsin levels in adult asthmatics. (Articolo in rivista)

Type
Label
  • Effect of age and asthma duration upon elastase and alpha1-antitrypsin levels in adult asthmatics. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1183/09031936.03.00112302 (literal)
Alternative label
  • Vignola AM, Bonanno A, Profita M, Riccobono L, Scichilone N, Spatafora M, Bousquet J, Bonsignore G, Bellia V. (2003)
    Effect of age and asthma duration upon elastase and alpha1-antitrypsin levels in adult asthmatics.
    in The European respiratory journal
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Vignola AM, Bonanno A, Profita M, Riccobono L, Scichilone N, Spatafora M, Bousquet J, Bonsignore G, Bellia V. (literal)
Pagina inizio
  • 795 (literal)
Pagina fine
  • 801 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • E stato studiato l'elastase/alfa antitripsina sui giovani e sugli anziani. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Impact Factor: 2.989 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Questo studio indica che l'invecchiamento non necessariamente porta ad un progressivo squilibrio del sistema elastase/alfa antitripsina nell'asma e suggerisce che una importante variabile dello sviluppo del rimodellamento delle vie aeree sia nei giovani che negli anziani asmatici è rappresentato dalla durata della malattia. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Medicina Generale e Pneumologia, Universita di Palermo. (literal)
Titolo
  • Effect of age and asthma duration upon elastase and alpha1-antitrypsin levels in adult asthmatics. (literal)
Abstract
  • In asthmatic subjects an imbalance between elastase and alpha1-antitrypsin (alpha1-PI) exists. This study aims to evaluate whether ageing per se affects the levels of elastase. Both young and elderly asthmatics with comparable severity and duration of disease, as well as young and elderly healthy subjects, underwent an induced sputum procedure to measure levels of elastase and alpha1-PI. The percentage of sputum neutrophils and eosinophils was higher in young and elderly asthmatics than in young and elderly controls. The levels of both total and active elastase were significantly higher in young and elderly asthmatics than in young and elderly controls, and directly correlated with the percentage of neutrophils. In addition, in both young and elderly asthmatics the levels of total and active elastase were negatively correlated with forced expiratory volume in one second values, but positively correlated with the duration of the disease. This study indicates that ageing per se does not necessarily lead to a progressive elastase/alpha1-antitrypsin imbalance in asthma, and suggests that an important variable in the development of airway remodelling in both young and elderly asthmatics is represented by the duration of the disease (literal)
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