http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11995
Fibrinogen, inflammation and concentric left ventricular hypertrophy in chronic renal failure. (Articolo in rivista)
- Type
- Label
- Fibrinogen, inflammation and concentric left ventricular hypertrophy in chronic renal failure. (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Zoccali C, Benedetto FA, Mallamaci F, Tripepi G, Cutrupi S, Parlongo S, Malatino LS, Bonanno G, Rapisarda F, Fatuzzo P, Seminara G, Nicocia G, Buemi M. (2003)
Fibrinogen, inflammation and concentric left ventricular hypertrophy in chronic renal failure.
in European journal of clinical investigation (Print)
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- Zoccali C, Benedetto FA, Mallamaci F, Tripepi G, Cutrupi S, Parlongo S, Malatino LS, Bonanno G, Rapisarda F, Fatuzzo P, Seminara G, Nicocia G, Buemi M. (literal)
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- ISI Web of Science (WOS) (literal)
- Titolo
- Fibrinogen, inflammation and concentric left ventricular hypertrophy in chronic renal failure. (literal)
- Abstract
- We investigated the relationship between fibrinogen and
echocardiographic measurements of left ventricular (LV) geometry and LV function
in a group of 192 patients with end stage renal disease (ESRD). RESULTS:
Patients in the third fibrinogen tertile had higher mean wall thickness (MWT),
relative wall thickness (RWT) and left ventricular mass index (LVMI) and lower
LV end diastolic diameter and LV ejection fraction than those in the other
tertiles. On multivariate analysis fibrinogen resulted to be an independent
correlate of MWT (P = 0.001) and RWT (P = 0.0001) and the first factor in rank
explaining the variance in LV ejection fraction (P = 0.0001). Left ventricular
concentric hypertrophy was more prevalent (P = 0.001) in patients in the third
fibrinogen tertile (n = 35, 54%) than in those in the second (n = 24, 37%) and
first (n = 13, 21%) tertiles. In a multiple logistic regression model patients
in the third tertile of fibrinogen had a risk for left ventricular concentric
hypertrophy that was 3.56 (95% CI: 1.56-8.14) fold higher than in those in the
first tertile (P = 0.003). CONCLUSIONS: Elevated fibrinogen is independently
associated with LV concentric hypertrophy and systolic dysfunction in ESRD
patients. These relationships may contribute to the negative prognostic impact
of elevated fibrinogen levels in ESRD.
(literal)
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