Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients (Articolo in rivista)

Type
Label
  • Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Mallamaci F., Zoccali C., Tripepi G., Fermo I., Benedetto F. A., Cataliotti A., Bellanuova I., Malatino L. S., Soldarini A. (2002)
    Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients
    in Kidney international
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mallamaci F., Zoccali C., Tripepi G., Fermo I., Benedetto F. A., Cataliotti A., Bellanuova I., Malatino L. S., Soldarini A. (literal)
Pagina inizio
  • 609 (literal)
Pagina fine
  • 614 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 61 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients (literal)
Abstract
  • BACKGROUND: We prospectively tested the prediction power of homocysteinemia for all-cause and cardiovascular outcomes in a cohort of 175 hemodialysis patients followed for 29 +/- 12 months. METHODS: Survival analysis was performed by the Cox's proportional hazard model and data were expressed as hazard ratio and 95% confidence interval (CI). RESULTS: During the follow-up period 51 patients died, 31 of them (61%) of cardiovascular causes and 16 patients developed non-fatal atherothrombotic complications. Plasma total homocysteine was an independent predictor of cardiovascular mortality (P=0.01). Combined analysis of fatal and non- fatal atherothrombotic events showed that homocysteine was a strong and independent predictor of these outcomes because the risk of these events was 8.2 times higher (95% CI 1.9 to 32.2) in patients in the third homocysteine tertile than in those in the first tertile (P=0.005). CONCLUSIONS: There is a clear association between hyperhomocysteinemia and incident cardiovascular mortality and atherothrombotic events in hemodialysis patients. Intervention studies are needed to determine whether the accumulation of this substance has a causal role in the pathogenesis of cardiovascular damage in patients undergoing hemodialysis. (literal)
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