The role of the Formamide/Zirconia system in the synthesis of nucleobases and biogenic carboxylic acid derivatives (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The role of the Formamide/Zirconia system in the synthesis of nucleobases and biogenic carboxylic acid derivatives (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Saladino R., Neri V., Crestini C., Costanzo, G., Graciotti, M., And Di Mauro E. (2010)
  The role of the Formamide/Zirconia system in the synthesis of nucleobases and biogenic carboxylic acid derivatives
  in Journal of molecular evolution
  (literal)

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• Saladino R., Neri V., Crestini C., Costanzo, G., Graciotti, M., And Di Mauro E. (literal)

Pagina inizio

• 100 (literal)

Pagina fine

• 110 (literal)

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• 71 (literal)

Rivista

• Journal of molecular evolution (Rivista)

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• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

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• R. Saladino (&) ? V. Neri Dipartimento A.B.A.C., Universita` della Tuscia, Via San Camillo De Lellis, 01100 Viterbo, Italy e-mail: saladino@unitus.it C. Crestini Dipartimento di Scienze e Tecnologie Chimiche, Universita` ''Tor Vergata'', 00133 Rome, Italy G. Costanzo Istituto di Biologia e Patologia Molecolari, CNR, 00185 Rome, Italy M. Graciotti ? E. Di Mauro (&) Fondazione ''Istituto Pasteur, Fondazione Cenci Bolognetti'', c/o Dipartimento di Genetica e Biologia Molecolare, Universita` ''La Sapienza'', P.le Aldo Moro, 5, 00185 Rome, Italy e-mail: ernesto.dimauro@uniroma1.it (literal)

Titolo

• The role of the Formamide/Zirconia system in the synthesis of nucleobases and biogenic carboxylic acid derivatives (literal)

Abstract

• We describe the one-pot synthesis of a large variety of nucleic acid bases and related compounds from formamide in the presence of zirconium minerals as catalysts. The major products observed are: purine, 2-hydroxy pyrimidine, 5-hydroxy pyrimidine, isocytosine, adenine, urea, and carbodiimide. The synthesis of low molecular weight amides and carboxylic acid derivatives (intermediates of extant metabolism) was also observed: glyoxylamide, glycolic-, lactic-, succinic-, oxalic-, fumaric-, and maleic acids. As the major problem in the origin of informational polymers is the instability of their precursors, we also investigated the effects of zirconia minerals on the stability of ribooligonucleotides in formamide and in water. The relevance of these findings with respect to the origin of informational polymers and primordial metabolism is discussed. (literal)

Prodotto di

• Struttura e funzione di Acidi nucleici e Cromatina. Epigenetica (SV.P14.009.001) (Modulo)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• ERNESTO DI MAURO (Unità di personale esterno)
• GIOVANNA MARIA COSTANZO (Unità di personale interno)

Incoming links:

Autore CNR di

• ERNESTO DI MAURO (Unità di personale esterno)
• GIOVANNA MARIA COSTANZO (Unità di personale interno)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Struttura e funzione di Acidi nucleici e Cromatina. Epigenetica (SV.P14.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of molecular evolution (Rivista)