TRAPPII function is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• TRAPPII function is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1242/jcs.054536 (literal)

Alternative label

• Robinett C.C.; Giansanti M.G.;Gatti M.; Fuller M.T. (2009)
  TRAPPII function is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells
  in Journal of cell science; COMPANY OF BIOLOGISTS LTD, CAMBRIDGE (Regno Unito)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Robinett C.C.; Giansanti M.G.;Gatti M.; Fuller M.T. (literal)

Pagina inizio

• 4526 (literal)

Pagina fine

• 4534 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 122 (literal)

Rivista

• Journal of cell science (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 24 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA 2. Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA 3. Univ Roma La Sapienza, Inst Pasteur, Fdn Cenci Bolognetti, Rome, Italy 4. Univ Roma La Sapienza, CNR, Dipartimento Genet & Biol Mol, IBPM, Rome, Italy (literal)

Titolo

• TRAPPII function is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells (literal)

Abstract

• Although membrane addition is crucial for cytokinesis in many animal cell types, the specific mechanisms supporting cleavage furrow ingression are not yet understood. Mutations in the gene brunelleschi (bru), which encodes the Drosophila ortholog of the yeast Trs120p subunit of TRAPPII, cause failure of furrow ingression in male meiotic cells. In non-dividing cells, Brunelleschi protein fused to GFP is dispersed throughout the cytoplasm and enriched at Golgi organelles, similarly to another Drosophila TRAPPII subunit, dBet3. Localization of the membrane-trafficking GTPase Rab11 to the cleavage furrow requires wild-type function of bru, and genetic interactions between bru and Rab11 increase the failure of meiotic cytokinesis and cause synthetic lethality. bru also genetically interacts with four wheel drive (fwd), which encodes a PI4K beta, such that double mutants exhibit enhanced failure of male meiotic cytokinesis. These results suggest that Bru cooperates with Rab11 and PI4K beta to regulate the efficiency of membrane addition to the cleavage furrow, thus promoting cytokinesis in Drosophila male meiotic cells. (literal)

Editore

• Company of biologists (Editore)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)

Autore CNR

• MARIA GRAZIA GIANSANTI (Persona)
• MAURIZIO GATTI (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "TRAPPII function is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MAURIZIO GATTI (Unità di personale esterno)
• MARIA GRAZIA GIANSANTI (Persona)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of cell science (Rivista)

Editore di

• Company of biologists (Editore)

Insieme di parole chiave di

• Keywords of "TRAPPII function is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells" (Insieme di parole chiave)