MicroRNA profiling in human medulloblastoma (Articolo in rivista)

Type
Label
  • MicroRNA profiling in human medulloblastoma (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Ferretti E; De Smaele E; Po A; Di Marcotullio L; Tosi E; Espinola MSB; Di Rocco C; Riccardi R; Giangaspero F; Farcomeni A; Nofroni I; Laneve P; Gioia U; Caffarelli E; Bozzoni I; Screpanti I; Gulino A. (2009)
    MicroRNA profiling in human medulloblastoma
    in International journal of cancer (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ferretti E; De Smaele E; Po A; Di Marcotullio L; Tosi E; Espinola MSB; Di Rocco C; Riccardi R; Giangaspero F; Farcomeni A; Nofroni I; Laneve P; Gioia U; Caffarelli E; Bozzoni I; Screpanti I; Gulino A. (literal)
Pagina inizio
  • 568 (literal)
Pagina fine
  • 577 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 124 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Ferretti E, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy De Smaele E, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Po A, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Di Marcotullio L, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Tosi E, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Espinola MSB, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Di Rocco C, Neurosurgery Institute, Catholic University, Rome, Italy Riccardi R, Pediatrics Department, Catholic University, Rome, Italy Giangaspero F, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy;Neuromed Institute, Pozzilli (IS), Italy Farcomeni A, Statistics Section, Department of Experimental Medicine, Sapienza University of Rome, Rome Nofroni I, Statistics Section, Department of Experimental Medicine, Sapienza University of Rome, Rome Laneve P, Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy Gioia U, Pasteur Institute, Cenci-Bolognetti Foundation, Rome, Italy; Department of Genetics and Molecular Biology, Sapienza University of Rome, Rome, Italy Caffarelli E, Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy Bozzoni I, Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy;Pasteur Institute, Cenci-Bolognetti Foundation, Rome;Department of Genetics and Molecular Biology, Sapienza University of Rome, Rome, Italy Screpanti I, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy;Pasteur Institute, Cenci-Bolognetti Foundation, Rome, Italy Gulino A, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy;Neuromed Institute, Pozzilli (IS), Italy; Pasteur Institute, Cenci-Bolognetti Foundation, Rome, Italy (literal)
Titolo
  • MicroRNA profiling in human medulloblastoma (literal)
Abstract
  • Medulloblastoma is an aggressive brain malignancy with high incidence in childhood. Current treatment approaches have limited efficacy and severe side effects. Therefore, new risk-adapted therapeutic strategies based on molecular classification are required. MicroRNA expression analysis has emerged as a powerful tool to identify candidate molecules playing an important role in a large number of malignancies. However, no data are yet available on human primary medulloblastomas. A high throughput microRNA expression profiles was performed in human primary medulloblastoma specimens to investigate microRNA involvement in medulloblastoma carcinogenesis. We identified specific microRNA expression patterns which distinguish medulloblastoma differing in histotypes (anaplastic, classic and desmoplastic), in molecular features (ErbB2 or c-Myc overexpressing tumors) and in disease-risk stratification. MicroRNAs expression profile clearly differentiates medulloblastoma from either adult or fetal normal cerebellar tissues. Only a few microRNAs displayed upregulated expression, while most of them were downregulated in tumor samples, suggesting a tumor growth-inhibitory function. This property has been addressed for miR-9 and miR-125a, whose rescued expression promoted medulloblastoma cell growth arrest and apoptosis while targeting the proproliferative truncated TrkC isoform. In conclusion, misregulated microRNA expression profiles characterize human medulloblastomas, and may provide potential targets for novel therapeutic strategies. (literal)
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