The artificial zinc finger protein 'Blues' binds the enhancer of the fibroblast growth factor 4 and represses transcription. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The artificial zinc finger protein 'Blues' binds the enhancer of the fibroblast growth factor 4 and represses transcription. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Libri V; Onori A; Fanciulli M; Passananti C; Corbi N. (2004)
  The artificial zinc finger protein 'Blues' binds the enhancer of the fibroblast growth factor 4 and represses transcription.
  in FEBS letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Libri V; Onori A; Fanciulli M; Passananti C; Corbi N. (literal)

Pagina inizio

• 75 (literal)

Pagina fine

• 80 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 560 (literal)

Rivista

• FEBS letters (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Medicina Sperimentale, Via Vetoio, Coppito 2, Università del L'Aquila, 67100 L'Aquila, Italy; Istituto Biologia e Patologia Molecolari, CNR, Viale Marx 43, 00137 Rome, Italy; Laboratorio \"B\", Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy; Istituto Biologia e Patologia Molecolari, CNR, Viale Marx 43, 00137 Rome, Italy;Istituto Biologia e Patologia Molecolari, CNR, Viale Marx 43, 00137 Rome, Italy. (literal)

Titolo

• The artificial zinc finger protein 'Blues' binds the enhancer of the fibroblast growth factor 4 and represses transcription. (literal)

Abstract

• The design of novel genes codifying for artificial transcription factors represents a powerful tool in biotechnologies and medicine. We have engineered a new zinc finger based transcription factor, named Blues, able to bind and possibly to modify the expression of the growth factor FGF-4 (K-fgf), originally identified as an oncogene. Blues encodes for a three-zinc finger peptide and was constructed to target the nine base pair DNA sequence: \" 5' -GTT-TGG-ATG- 3' \", internal to the murine FGF-4 enhancer, in proximity of Sox-2 and Oct-3 DNA binding sites. Our final aim is to generate a model system based on artificial zinc finger genes to study the biological role of FGF-4 during development and tumorigenesis. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• NICOLETTA CORBI (Persona)
• CLAUDIO PASSANANTI (Unità di personale interno)
• ANNALISA ONORI (Persona)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR di

• CLAUDIO PASSANANTI (Unità di personale interno)
• ANNALISA ONORI (Persona)
• NICOLETTA CORBI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• FEBS letters (Rivista)