Synthetic zinc finger peptides: old and novel applications. (Articolo in rivista)

Type
Label
  • Synthetic zinc finger peptides: old and novel applications. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Corbi N; Libri V; Onori A; Passananti C. (2004)
    Synthetic zinc finger peptides: old and novel applications.
    in Biochemistry and cell biology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Corbi N; Libri V; Onori A; Passananti C. (literal)
Pagina inizio
  • 428 (literal)
Pagina fine
  • 436 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 82 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Biologia e Patologia Molecolari (IBPM), Viale Marx 43, 00137, Rome, Italy;Istituto di Biologia e Patologia Molecolari (IBPM), Viale Marx 43, 00137, Rome, Italy;Istituto di Biologia e Patologia Molecolari (IBPM), Viale Marx 43, 00137, Rome, Italy. (literal)
Titolo
  • Synthetic zinc finger peptides: old and novel applications. (literal)
Abstract
  • In the last decade, the efforts in clarifying the interaction between zinc finger proteins and DNA targets strongly stimulated the creativity of scientists in the field of protein engineering. In particular, the versatility and the modularity of zinc finger (ZF) motives make these domains optimal building blocks for generating artificial zinc finger peptides (ZFPs). ZFPs can act as transcription modulators potentially able to control the expression of any desired gene, when fused to an appropriate effector domain. Artificial ZFPs open the possibility to re-program the expression of specific genes at will and can represent a powerful tool in basic science, biotechnology and gene therapy. In this review we will focus on old, novel and possible future applications of artificial ZFPs. (literal)
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