Synthesis and Degradation of Nucleobases and Nucleic Acids by  Formamide in the Presence of  Montmorillonites. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synthesis and Degradation of Nucleobases and Nucleic Acids by  Formamide in the Presence of  Montmorillonites. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Saladino R, Crestini C, Ciambecchini U, Ciciriello F, Costanzo G, Di Mauro E. (2004)
  Synthesis and Degradation of Nucleobases and Nucleic Acids by  Formamide in the Presence of  Montmorillonites.
  in ChemBioChem (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Saladino R, Crestini C, Ciambecchini U, Ciciriello F, Costanzo G, Di Mauro E. (literal)

Pagina inizio

• 1558 (literal)

Pagina fine

• 1566 (literal)

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• 5 (literal)

Rivista

• ChemBioChem (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• ISI Web of Science (WOS) (literal)

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• [a] Prof. R. Saladino, U. Ciambecchini Dipartimento A.B.A.C. , Università della Tuscia Via San Camillo De Lellis, 01100 Viterbo (Italy) Fax: (+39) 076-135-7242 E-mail: saladino@unitus.it [b] Dr. C. Crestini Dipartimento di Scienze e Tecnologie Chimiche Università \"Tor Vergata\" 00133 Rome (Italy) [c] Dr. F. Ciciriello, Dr. G. Costanzo Istituto di Biologia e Patologia Molecolari, CNR 00185 Rome (Italy) [d] Prof. E. Di Mauro Fondazione \"Istituto Pasteur, Fondazione Cenci Bolognetti\" c/o Dipartimento di Genetica e Biologia Molecolare Università \"La Sapienza\" P.le Aldo Moro 5, 00185 Rome (Italy) Fax: (+39) 064-991-2880 E-mail: ernesto.dimauro@uniroma1.it (literal)

Titolo

• Synthesis and Degradation of Nucleobases and Nucleic Acids by  Formamide in the Presence of  Montmorillonites. (literal)

Abstract

• We describe the role of formamide, a product of the hydrolysis of hydrogen cyanide, as precursor of several components of nucleic acids under prebiotic conditions. When formamide is heated in the presence of montmorillonites, the efficient one pot synthesis of purine, adenine, cytosine, and uracil is obtained. Along with these nucleobases, several components of the inosine pathway are obtained: 5-aminoimidazole-4-carboxamide, 5-formamido-imidazole-4-carboxamide and hypoxanthine. This almost complete catalogue of nucleic acid precursors is accompanied by N-9-formylpurine, which, containing a masked glycosidic bond in its formyl moiety, is a plausible precursor of purine acyclonucleosides. In addition, montmorillonites differently affect the rate of degradation of nucleobases with embedded in 2'-deoxyoligonucleotides; namely, montmorillonites protect adenine and guanine from the degradative action of formamide, while thymine degradation is enhanced. The oligonucleotide backbone reactivity to formamide is also affected; this shows that the interaction with montmorillonites modifies the rate of abstraction of the Halpha and Hbeta protons on the sugar moieties. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• GIOVANNA MARIA COSTANZO (Unità di personale interno)
• ERNESTO DI MAURO (Persona)

Incoming links:

Autore CNR di

• ERNESTO DI MAURO (Persona)
• GIOVANNA MARIA COSTANZO (Unità di personale interno)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ChemBioChem (Rivista)