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Australin: A Chromosomal Passenger Protein required specifically for Drosophila male meiosis. (Articolo in rivista)

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Australin: A Chromosomal Passenger Protein required specifically for Drosophila male meiosis. (Articolo in rivista) (literal)

Anno

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Alternative label

Gao S.; Giansanti MG.; Buttrick GJ.; Ramasubramanyan S.; Auton A.; Gatti M.; Wakefield JG (2008)
Australin: A Chromosomal Passenger Protein required specifically for Drosophila male meiosis.
in The Journal of cell biology; Rockefeller University Press, New York (Stati Uniti d'America)
(literal)

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Gao S.; Giansanti MG.; Buttrick GJ.; Ramasubramanyan S.; Auton A.; Gatti M.; Wakefield JG (literal)

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1. Univ Oxford, Dept Zool, Oxford OX1 3PS, England 2. Univ Roma La Sapienza, Ist Pasteur, Fondaziane Cenci Bolognetti, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy 3. Univ Roma La Sapienza, Consiglio Nazl Ric, Ist Biol & Patol Mol, I-00185 Rome, Italy 4. Univ Oxford, Life Sci Interface Doctoral Training Ctr, Oxford OX1 3QD, England 5. Univ Oxford, Dept Stat, Oxford OX1 3SY, England (literal)

Titolo

Australin: A Chromosomal Passenger Protein required specifically for Drosophila male meiosis. (literal)

Abstract

The chromosomal passenger complex (CPC) which is composed of conserved proteins aurora B, inner centromere protein (INCENP), survivin, and Borealin/DASRA, localizes to chromatin, kinetochores, microtubules, and the cell cortex in a cell cycle-dependent manner. The CPC is required for multiple aspects of cell division. Here we find that Drosophila melanogaster encodes two Borealin paralogues, Borealin-related (Borr) and Australin (Aust). Although Barr is a passenger in all mitotic tissues studied, it is specifically replaced by Aust for the two male meiotic divisions. We analyzed oust mutant spermatocytes to assess the effects of fully inactivating the Aust-dependent functions of the CPC. Our results indicate that Aust is required for sister chromatid cohesion, recruitment of the CPC to kinetochores, and chromosome alignment and segregation but not for meiotic histone phosphorylation or spindle formation. Furthermore, we show that the CPC is required earlier in cytokinesis than previously thought; cells lacking Aust do not initiate central spindle formation, accumulate anillin or actin at the cell equator, or undergo equatorial constriction. (literal)

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