http://www.cnr.it/ontology/cnr/individuo/prodotto/ID11545
Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo (Articolo in rivista)
- Type
- Label
- Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Alternative label
Di Felice F, Chiani F, Camilloni G. (2008)
Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo
in Biochemical journal (Lond., 1984)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Di Felice F, Chiani F, Camilloni G. (literal)
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- ISI Web of Science (WOS) (literal)
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- Camilloni Giorgio (literal)
- Titolo
- Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo (literal)
- Abstract
- DNA topoisomerase I together with the other cellular DNA topoisomerases releases the torsional stress from DNA caused by processes such as replication, transcription and recombination. Despite the well-defined knowledge of its mechanism of action, DNA topoisomerase I in vivo activity has been only partially characterized. In fact the basic question concerning the capability of the enzyme to cleave and rejoin DNA wrapped around a histone octamer remains still unanswered. By studying both in vivo and in vitro the cleavage activity of DNA topoisomerase I in the presence of camptothecin on a repeated trinucleotide sequence, (TTA)(35), lying in chromosome XIII of Saccharomyces cerevisiae, we can conclude that nucleosomes represent a physical barrier for the enzyme activity. (literal)
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