The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. (Articolo in rivista)

Type
Label
  • The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Laneve P; Di Marcotullio L ; Gioia U; Fiori ME; Ferretti E; Gulino A; Bozzoni I; Caffarelli E (2007)
    The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells.
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Laneve P; Di Marcotullio L ; Gioia U; Fiori ME; Ferretti E; Gulino A; Bozzoni I; Caffarelli E (literal)
Pagina inizio
  • 7957 (literal)
Pagina fine
  • 7962 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 104 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Laneve P, Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche (Italy) Di Marcotullio L, Department of Experimental Medicine, University of Rome ''La Sapienza\", Rome Gioia U, Institute Pasteur Cenci-Bolognetti, Department of Genetics and Molecular Biology,University of Rome ''La Sapienza\", Rome Fiori ME, Institute Pasteur Cenci-Bolognetti, Department of Genetics and Molecular Biology,University of Rome ''La Sapienza\", Rome Ferretti E, Department of Experimental Medicine, University of Rome ''La Sapienza\", Rome Gulino A, Department of Experimental Medicine, University of Rome ''La Sapienza\", Rome Bozzoni I, Institute Pasteur Cenci-Bolognetti, Department of Genetics and Molecular Biology,University of Rome ''La Sapienza\", Rome; Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche (Italy) Caffarelli E, Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche (Italy) (literal)
Titolo
  • The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. (literal)
Abstract
  • MicroRNAs (miRNAs) are tiny noncoding RNAs whose function as modulators of gene expression is crucial for the proper control of cell growth and differentiation. Although the profile of miRNA expression has been defined for many different cellular systems, the elucidation of the regulatory networks in which they are involved is only just emerging. In this work, we identify a crucial role for three neuronal miRNAs (9, 125a, and 125b) in controlling human neuroblastoma cell proliferation. We show that these molecules act in an additive manner by repressing a common target, the truncated isoform of the neurotrophin receptor tropomyosin-related kinase C, and we demonstrate that the down-regulation of this isoform is critical for regulating neuroblastoma cell growth. Consistently with their function, these miRNAs were found to be down-modulated in primary neuroblastoma tumors. (literal)
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