Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ymgme.2006.02.015 (literal)

Alternative label

• Corbo RM; Prevost M; Raussens V; Gambina G; Moretto G; Scacchi R (2006)
  Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation.
  in Molecular genetics and metabolism (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Corbo RM; Prevost M; Raussens V; Gambina G; Moretto G; Scacchi R (literal)

Pagina inizio

• 261 (literal)

Pagina fine

• 269 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 89 (literal)

Rivista

• Molecular genetics and metabolism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CORBO Rosa Maria, Department of Biology and Biotechnology, Sapienza University, Rome, Italy SCACCHI Renato, CNR Institute of Molecular Biology and Pathology, Rome, Italy (literal)

Titolo

• Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variation. (literal)

Abstract

• Apolipoprotein E (APOE) is an important gene whose common polymorphism, and precisely the e*4 allele, has been reportedly associated with some disorders, including Alzheimer's disease (AD) and coronary artery disease. In the course of previous surveys on AD patients and healthy individuals some rare variants were detected by means of Isoelectric focusing and denaturing high-performance liquid chromatography techniques. After a mutation in a gene is identified, the problem arises to understand its effective significance. Structure modelling and phylogenetic analysis methods are widely used to establish the possible deleterious effect of mutations. In this study their usefulness in the analysis of APOE variants was evaluated. The two combined methods provided helpful indications for distinguishing between mutations possibly involved in AD susceptibility and not deleterious mutations. (c) 2006 Elsevier Inc. All rights reserved. (literal)

Prodotto di

• Basi molecolari ed impatto biologico della variabilità genetica e della plasticità genomica (SV.P13.006.001) (Modulo)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• RENATO SCACCHI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Basi molecolari ed impatto biologico della variabilità genetica e della plasticità genomica (SV.P13.006.001) (Modulo)

Autore CNR di

• RENATO SCACCHI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular genetics and metabolism (Rivista)