Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Bruno T.; De Nicola F.; Iezzi S. Lecis D.; D'Angelo C.; Di Padova M.; Corbi N.; Zannini L.; Jekimovs C.; Scarsella M.; Porrello A.; Crescenzi M.; Leonetti C.; Khanna K.K.; Soddu S.; Floridi A.; Passananti C .; Delia D.; Fanciulli, M. (2006)
  Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.
  in Cancer cell (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bruno T.; De Nicola F.; Iezzi S. Lecis D.; D'Angelo C.; Di Padova M.; Corbi N.; Zannini L.; Jekimovs C.; Scarsella M.; Porrello A.; Crescenzi M.; Leonetti C.; Khanna K.K.; Soddu S.; Floridi A.; Passananti C .; Delia D.; Fanciulli, M. (literal)

Pagina inizio

• 486 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 473 (literal)

Rivista

• Cancer cell (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Experimental Chemotherapy Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy; Laboratory B, Department of Therapeutic Programs Development, Regina Elena Cancer Institute, 00158 Rome, Italy; Department of Experimental Medicine, University of L'Aquila, 67100 L'Aquila, Italy; Department of Experimental Oncology, Istituto Nazionale Tumori, 20133 Milan, Italy; Istituto di Biologia e Patologia Molecolare, CNR, 00158 Rome, Italy; Department of Environment and Primary Prevention, High Institute of Health, 00161 Rome, Italy; Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia; 8Molecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, 00158 Rome, Italy 9Laboratory D, Department of Therapeutic Programs Development, Regina Elena Cancer (literal)

Titolo

• Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. (literal)

Abstract

• Che-1 is a RNA polymerase II-binding protein involved in the transcription of E2F target genes and induction of cell proliferation. Here we show that Che-1 contributes to DNA damage response and that its depletion sensitizes cells to anticancer agents. The checkpoint kinases ATM/ATR and Chk2 interact with Che-1 and promote its phosphorylation and accumulation in response to DNA damage. These Che-1 modifications induce a specific recruitment of Che-1 on the TP53 and p21 promoters. Interestingly, it has a profound effect on the basal expression of p53, which is preserved following DNA damage. Notably, Che-1 contributes to the maintenance of the G2/M checkpoint induced by DNA damage. These findings identify a mechanism by which checkpoint kinases regulate responses to DNA damage. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Controllo di proliferazione, differenziamento e morte cellulare (SV.P15.010.001) (Modulo)

Autore CNR

• NICOLETTA CORBI (Persona)
• CLAUDIO PASSANANTI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Controllo di proliferazione, differenziamento e morte cellulare (SV.P15.010.001) (Modulo)

Autore CNR di

• CLAUDIO PASSANANTI (Unità di personale interno)
• NICOLETTA CORBI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer cell (Rivista)