Incomplete sister chromatid separation of long chromosome arms. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Incomplete sister chromatid separation of long chromosome arms. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Rens W1, Torosantucci L2 , Degrassi F2 , Ferguson-Smith MA1. (2006)
  Incomplete sister chromatid separation of long chromosome arms.
  in Chromosoma (Berl., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Rens W1, Torosantucci L2 , Degrassi F2 , Ferguson-Smith MA1. (literal)

Pagina inizio

• 481 (literal)

Pagina fine

• 490 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 115 (literal)

Rivista

• Chromosoma (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Centre for Veterinary Science, University of Cambridge, Cambridge CB3 OES, UK 2 Institute for Molecular Biology and Pathology CNR, University 'La Sapienza', Rome 00185, Italy (literal)

Titolo

• Incomplete sister chromatid separation of long chromosome arms. (literal)

Abstract

• Chromosome segregation ensures the equal partitioning of chromosomes at mitosis. However, long chromosome arms may pose a problem for complete sister chromatid separation. In this paper we report on the analysis of cell division in primary cells from field vole Microtus agrestis, a species with 52 chromosomes including two giant sex chromosomes. Dual chromosome painting with probes specific for the X and the Y chromosomes showed that these long chromosomes are prone to mis-segregate, producing DNA bridges between daughter nuclei and micronuclei. Analysis of mitotic cells with incomplete chromatid separation showed that reassembly of the nuclear membrane, deposition of INner CENtromere Protein (INCENP)/Aurora B to the spindle midzone and furrow formation occur while the two groups of daughter chromosomes are still connected by sex chromosome arms. Late cytokinetic processes are not efficiently inhibited by the incomplete segregation as in a significant number of cell divisions cytoplasmic abscission proceeds while Aurora B is at the midbody. Live-cell imaging during late mitotic stages also revealed abnormal cell division with persistent sister chromatid connections. (literal)

Prodotto di

• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• FRANCESCA DEGRASSI (Unità di personale interno)
• LILIANA TOROSANTUCCI (Persona)

Incoming links:

Autore CNR di

• FRANCESCA DEGRASSI (Unità di personale interno)
• LILIANA TOROSANTUCCI (Persona)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Chromosoma (Rivista)