Aneuploidy-inducing capacity of two widely used pesticides. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Aneuploidy-inducing capacity of two widely used pesticides. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Mattiuzzo M , Fiore M , Ricordy R , Degrassi F . (2006)
  Aneuploidy-inducing capacity of two widely used pesticides.
  in Carcinogenesis (N.Y., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Mattiuzzo M , Fiore M , Ricordy R , Degrassi F . (literal)

Pagina inizio

• 2511 (literal)

Pagina fine

• 2518 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 27 (literal)

Rivista

• Carcinogenesis (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Molecular Biology and Pathology, CNR, Department of Genetics and Molecular Biology, University 'La Sapienza', Rome (literal)

Titolo

• Aneuploidy-inducing capacity of two widely used pesticides. (literal)

Abstract

• The aneuploidy-inducing activity of alachlor and dichlorvos, two pesticides representing an important source of human exposure to potential carcinogens, has been evaluated in a cytokinesis block micronucleus assay combined with anti-kinetochore (CREST) staining to detect chromosome loss and in situ hybridization with chromosome-specific centromeric probes for the analysis of non-disjunction. Cytofluorimetric analysis to assess potential interference of the chemicals with cell cycle progression and TUNEL assay to detect apoptosis were also performed. The results obtained show that both environmental compounds induced significant and doserelated increases of total micronuclei (MN) and CRESTpositive MN as compared with the concurrent solvent control. The chemicals were also capable of promoting chromosome non-disjunction. However, the two pesticides differed in their mode of action: alachlor induced both chromosomal aberrations and aneuploidy, while the genotoxic activity of dichlorvos was only related to aneuploidy induction. Cytofluorimetric analyses showed that dichlorvos caused a marked accumulation of cells in the G2/M phase of cell cycle and indicate a potential for this chemical to interfere with mitosis. Furthermore, dichlorvos induced CREST-positive MN at a concentration lower than the one producing apoptosis, suggesting that dichlorvos-induced aneuploid cells may persist in the growing cell population (literal)

Prodotto di

• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)
• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• MARTA MATTIUZZO (Persona)
• FRANCESCA DEGRASSI (Unità di personale interno)
• MARIO FIORE (Unità di personale interno)
• RUGGERO RICORDY (Persona)

Incoming links:

Autore CNR di

• RUGGERO RICORDY (Persona)
• FRANCESCA DEGRASSI (Unità di personale interno)
• MARIO FIORE (Unità di personale interno)
• MARTA MATTIUZZO (Persona)

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Meccanismi molecolari del ciclo cellulare e della mitosi (SV.P15.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Carcinogenesis (Rivista)