The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication. (Articolo in rivista)

Type
Label
  • The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Renzi F; Caffarelli E; Laneve P; Bozzoni I; Brunori M; Vallone B. (2006)
    The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication.
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Renzi F; Caffarelli E; Laneve P; Bozzoni I; Brunori M; Vallone B. (literal)
Pagina inizio
  • 12365 (literal)
Pagina fine
  • 12370 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 103 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Renzi F, Dipartimento di Scienze Biochimiche, University of Rome ''La Sapienza\", Rome Caffarelli E, Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Roma Laneve P, Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Roma Bozzoni I, Dipartimento di Genetica e Biologia Molecolare, University of Rome ''La Sapienza\", Rome;Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Roma Brunori M, Dipartimento di Scienze Biochimiche, University of Rome ''La Sapienza\", Rome Vallone B, Dipartimento di Scienze Biochimiche, University of Rome ''La Sapienza\", Rome (literal)
Titolo
  • The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication. (literal)
Abstract
  • Small nucleolar RNAs (snoRNAs) play a key role in eukaryotic ribosome biogenesis. In most cases, snoRNAs are encoded in introns and are released through the splicing reaction. Some snoRNAs are, instead, produced by an alternative pathway consisting of endonucleolytic processing of pre-mRNA. XendoU, the endoribonuclease responsible for this activity, is a U-specific, metal-dependent enzyme that releases products with 2'-3' cyclic phosphate termini. XendoU is broadly conserved among eukaryotes, and it is a genetic marker of nidoviruses, including the severe acute respiratory syndrome coronavirus, where it is essential for replication and transcription. We have determined by crystallography the structure of XendoU that, by refined search methodologies, appears to display a unique fold. Based on sequence conservation, mutagenesis, and docking simulations, we have identified the active site. The conserved structural determinants of this site may provide a framework for attempting to design antiviral drugs to interfere with the infectious nidovirus life cycle. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it