U86, a novel snoRNA with an unprecedented gene organization in yeast (Articolo in rivista)

Type
Label
  • U86, a novel snoRNA with an unprecedented gene organization in yeast (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Filippini D. 1, Renzi F. 1, Bozzoni I. 1, Caffarelli E. 2 (2001)
    U86, a novel snoRNA with an unprecedented gene organization in yeast
    in Biochemical and biophysical research communications (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Filippini D. 1, Renzi F. 1, Bozzoni I. 1, Caffarelli E. 2 (literal)
Pagina inizio
  • 16 (literal)
Pagina fine
  • 21 (literal)
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  • A novel small nucleolar RNA, U86, was identified in different organisms (human, amphibian and yeast). While the genomic organization in vertebrates appears to be conserved, in yeast U86 has a novel arrangement: it is embedded inside an open reading frame. The fact that, both in amphibian and in yeast, the synthesis of U86 is alternative to that of the co-transcribed mRNA, together with the observation that this snoRNA does not shows significant complementarity towards the methylation substrates (rRNAs and snRNAs) suggest a possible, new role for such RNA as regulator of gene expression. The paper is published in a peer-reviewed international journal with an impact factor of 2.946. (literal)
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  • 288 (literal)
Rivista
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  • I. Bozzoni a disposizione dell'IBPM (literal)
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  • The Xenopus laevis Nop56 gene (XNOP56), coding for a snoRNP-specific factor, belongs to the 5’-TOP gene family. As many 5’-TOP genes, XNOP56 contains a previously unidentified intron-encoded snoRNA,U86. This snoRNA belongs to the box C/D snoRNA family whose components direct the 2’-O-ribose methylation of rRNAs and snRNAs. This role is played by means of long regions of complementarity to highly conserved sequences of RNA substrates. U86 snoRNA was found as a highly conserved species in yeast and human. While in human it displays the same genomic localization, in yeast it has an unprecedented gene organization: it is encoded inside an open-reading frame. Both in X. laevis and yeast, the synthesis of U86 snoRNA appears to be alternative to that of the co-transcribed mRNA. Despite the overall homology, the three U86 snoRNAs do not display significant sequence complementarity to rRNA or snRNA sequences, suggesting a role different from that of methylation. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 CNR (C.S. sugli Acidi Nucleici), 2 UNI Sapienza (Istituto Pasteur - Fondazione Cenci-Bolognetti). (literal)
Titolo
  • U86, a novel snoRNA with an unprecedented gene organization in yeast (literal)
Abstract
  • The Xenopus laevis Nop56 gene (XNOP56), coding for a snoRNP-specific factor, belongs to the 5¢-TOP gene family. XNOP56, as many 5¢-TOP genes, contains an intron-encoded snoRNA. This previously unidentified RNA, named U86, was found as a highly conserved species in yeast and human. While in human it is also encoded in an intron of the hNop56 gene, in yeast it has an unprecedented gene organization: it is encoded inside an open-reading frame. Both in X. laevis and yeast, the synthesis of U86 snoRNA appears to be alternative to that of the cotranscribed mRNA. Despite the overall homology, the three U86 snoRNAs do not show strong conservation of the sequence upstream from the box D and none of them displays significant sequence complementarity to rRNA or snRNA sequences, suggesting a role different from that of methylation. (literal)
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