http://www.cnr.it/ontology/cnr/individuo/prodotto/ID113589

Innovative Device for Intervertebral Disc Replacement: Design, Preparation and Characterization (Abstract/Poster in atti di convegno)

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Innovative Device for Intervertebral Disc Replacement: Design, Preparation and Characterization (Abstract/Poster in atti di convegno) (literal)

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A. Gloria , F. Causa , R. De Santis , P. A. Revell , K.E. Tanner , L. Nicolais, L. Ambrosio (2006)
Innovative Device for Intervertebral Disc Replacement: Design, Preparation and Characterization
in International Conference on Advances in Biomaterials for Drug Delivery and Regenerative Medicine, Capri
(literal)

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A. Gloria , F. Causa , R. De Santis , P. A. Revell , K.E. Tanner , L. Nicolais, L. Ambrosio (literal)

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The mechanical integrity of the intervertebral disc (IVD) and its degeneration represent one of the major causes of low back pain. The IVD role results in distributing loads and absorbing shock while providing flexibility. Since the presence of a damaged disc alters the structure and biomechanics of the spine, an artificial intervertebral disc seems the ideal solution for restoring dynamic physiological motion at a similar level to that of a healthy disc. Thus, the aim of this work was to design a novel composite total intervertebral disc prosthesis and to investigate its mechanical behavior. Static and dynamic-mechanical tests have shown an appropriate mechanical behavior in the physiological range. On the other hand, creep-fatigue tests have shown endurance, resistance to long-term compressive creep and a high dimension stability. However, by varying the composition of the hydrogelic matrix, the winding angle and the amount of the PET fibers, it is possible to modulate the hydrophilicity and the mechanical properties of the composite structure. The production process used could be applied for manufacturing appropriate components for a human total intervertebral disc device. (literal)

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Institute of Composite and Biomedical Materials, (IMCB-CNR), P.le Tecchio 80, 80125, Naples, Italy. Department of Experimental and Clinical Medicine, University of Magna Graecia, Germaneto, 88100, Catanzaro, Italy. 3 Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London, UK. Queen Mary University of London, Mile End Road, London E1 4NS, UK. (literal)

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