http://www.cnr.it/ontology/cnr/individuo/prodotto/ID113569

Biodegradable composite scaffolds by filament winding technology for bone tissue engineering (Abstract/Poster in atti di convegno)

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Biodegradable composite scaffolds by filament winding technology for bone tissue engineering (Abstract/Poster in atti di convegno) (literal)

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V.Guarino, F.Causa, P.A.Netti, M.P. Ginebra, J.Planell, L.Ambrosio (2006)
Biodegradable composite scaffolds by filament winding technology for bone tissue engineering
in International Conference on Advances in Biomaterials for Drug Delivery and Regenerative Medicine, Capri
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Biodegradable polymers have been used extensively as scaffolding materials to generate new tissues. In this study, poly å-caprolactone was selected in comparison with the other resorbable polymers, due to its higher flexibility and to feasibility of process. Moreover, the presence of bioactive particles (such as Calcium Phosphates) in the polymer matrix improves bone formation by osteoblasts and mesenchimal cells [1]. The addition of biodegradable fibers (polylactic acid) through filament winding technique increases mechanical properties and mimic bone-like behavior without significantly affecting scaffold porosity. The processing methodology for preparing scaffolds structures must not adversely affect the materials properties, namely their biocompatibility or chemical properties. The technique should be accurate and consistent, regarding porosity, pore size, pore distribution and interconnectivity. In this study scaffolds were obtained by a combination of phase inversion/salt leaching technique with filament winding technique in order to reach a good balance between morphological requirements and mechanical properties for bone regeneration. (literal)

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Institute of Biomedical and Composite Materials CNR and Interdisciplinary Research Centre in Biomaterials CRIB, University of Naples Federico II P.le Tecchio 80, 80125, Naples, Italy - Dept. Experimental and Clinical Medicine -University of Magna Graecia, Germaneto Catanzaro, Italy - Department of Materials Science and Metallurgy, Technical University of Catalonia (UPC), Barcelona, Spain (literal)

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