http://www.cnr.it/ontology/cnr/individuo/prodotto/ID113549

Materiali bioattivi per lingegneria tissutale dello scheletro (Comunicazione a convegno)

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Materiali bioattivi per lingegneria tissutale dello scheletro (Comunicazione a convegno) (literal)

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L. Ambrosio (2004)
Materiali bioattivi per lingegneria tissutale dello scheletro
in VI Congresso Nazionale della Italian Orthopaedic Research (IORS), Bologna
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

Tissue engineering regards the generation, regeneration, augmentation or limitation of the structure and function of living tissues by the application of scientific and engineering principles. Skeletal defects resulting from tumor resection, congenital abnormalities or trauma often require surgical intervention to restore the function. Skeletal tissues are under extensive investigation in tissue engineering research and beside the biological issues, the scaffolds design plays an important role. A number of biodegradable and bioabsorbable materials as well as scaffold designs, have been experimentally and, in some cases clinically studied. An appropriate scaffold should posses highly porous with interconnected pore network for cell growth and flow transport of nutrient and metabolic waste; biocompatible and bioresorbable with a controlled degradation and resorption rate to match cell/tissue growth, suitable surface chemistry for cell attachment, proliferation and differentiation, and mechanical properties to match those of the implanted tissue. Synthetic biodegardable polymers and inorganic materials are promising as extracellular matrix analogue to facilitated tissue development and growth; these include: poly-glycolic acid, poly-l-lactic acid, copolymers, poly-caprolactones, hydroxyapatite, tricalcium phosphates (literal)

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