The spatial distribution and the temporal evolution of the matrix regulate cell function (Abstract/Poster in atti di convegno)

Type

• Abstract/Poster in atti di convegno (Classe)
• Prodotto della ricerca (Classe)

Label

• The spatial distribution and the temporal evolution of the matrix regulate cell function (Abstract/Poster in atti di convegno) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Borselli C, Oliviero O., De Rosa E., Battista S., Ambrosio L., Netti P.A (2006)
  The spatial distribution and the temporal evolution of the matrix regulate cell function
  in 1st Chinese-European Symposium on Biomaterials in Regenerative Medicine, Suzhou-China
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Borselli C, Oliviero O., De Rosa E., Battista S., Ambrosio L., Netti P.A (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Apart from composition, also the spatial distribution and the temporal evolution of the matrix molecular cues may play important role in controlling and guide the morphogenetic processes. In this context, we have evaluated the possibility of providing a directional guidance for in vitro angiogenesis by shaping the distribution of solid state molecules within three-dimensional semi-interpenetrated polymer networks (SIPN) with particular regard on the temporal evolution of the matrix macromolecular components. The success of any tissue engineering (TE) implant relies upon the ability of the scaffold to induce and guide an adequate vascular ingrowth throughout the cellular construct. Our results demonstrate that the temporal evolution of collagen-hyaluronic acid distribution is able to affect the initiation and the quantity of the angiogenic sprout and interestingly the spatial 3D modulation of collagen-hyaluronic acid distribution is able to affect the directionality of three-dimensional capillary like structures. Our experimental findings represent direct evidence that gradients of matrices have the potential to influence the direction of angiogenic sprouting, providing a platform for spatially controlled vascularization of engineered tissues. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Università di Napoli Federico II (literal)

Titolo

• The spatial distribution and the temporal evolution of the matrix regulate cell function (literal)

Prodotto di

• Istituto per i materiali compositi e biomedici (IMCB) (Istituto)
• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)

Autore CNR

• SABRINA BATTISTA (Persona)
• LUIGI AMBROSIO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "The spatial distribution and the temporal evolution of the matrix regulate cell function" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto per i materiali compositi e biomedici (IMCB) (Istituto)
• Biomateriali ed ingegneria dei tessuti (PM.P02.004.002) (Modulo)

Autore CNR di

• LUIGI AMBROSIO (Unità di personale interno)
• SABRINA BATTISTA (Persona)

Insieme di parole chiave di

• Keywords of "The spatial distribution and the temporal evolution of the matrix regulate cell function" (Insieme di parole chiave)