http://www.cnr.it/ontology/cnr/individuo/prodotto/ID113531

Poly-e-Caprolactone Scaffolds with/without Stromal Cells in a Rabbit Femur Model (Abstract/Poster in atti di convegno)

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Poly-e-Caprolactone Scaffolds with/without Stromal Cells in a Rabbit Femur Model (Abstract/Poster in atti di convegno) (literal)

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L. Savarino, G. Ciapetti, C. Tarabusi, L. Ambrosio, P. Netti, S. Battista, F. Causa, O. Capitani, S. Pinna, S. Valentini, N. Baldini (2005)
Poly-e-Caprolactone Scaffolds with/without Stromal Cells in a Rabbit Femur Model
in 19th European Conference on Biomaterials, Sorrento
(literal)

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L. Savarino, G. Ciapetti, C. Tarabusi, L. Ambrosio, P. Netti, S. Battista, F. Causa, O. Capitani, S. Pinna, S. Valentini, N. Baldini (literal)

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of synthetic or natural biomaterials that promote migration, proliferation, and differentiation of bone cells have been introduced to improve bone defects repair as an alternative to bone allografts. However, the success of both such materials is limited, since they lack the osteogenic properties of autografts. It has been postulated that efficient regeneration can be obtained by supplementing a resorbable scaffold with competent cells, i.e. bone marrow stromal cells (BMSC). Among compatible polymers, poly-å-caprolactone(PCL) is receiving considerable attention due to its excellent physical properties, tissue compatibility, and controlled. In this research, the efficiency of PCL scaffolds, alone or seeded with autologous BMSC, to favour bone repair, was assessed in a non-critical size defect model created in New Zealand rabbit femurs. Femurs were retrieved 1 month after surgery, and the in vivo biocompatibility, as well as the osteogenic and angiogenic effects induced by the presence of scaffolds were histologically defined. (literal)

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