In vitro interactions between rabbit bone marrow precursor cells and PCL surface (Abstract/Poster in atti di convegno)

Type
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  • In vitro interactions between rabbit bone marrow precursor cells and PCL surface (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • G. Ciapetti, I. Amato, V. Devescovi, O. Capitani, G. Marletta, L. Ambrosio, P. Netti, N. Baldini (2005)
    In vitro interactions between rabbit bone marrow precursor cells and PCL surface
    in 19th European Conference on Biomaterials, Sorrento
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • G. Ciapetti, I. Amato, V. Devescovi, O. Capitani, G. Marletta, L. Ambrosio, P. Netti, N. Baldini (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Prior to the clinical application of engineered materials, the efficacy of cell/scaffold constructs has to be verified in vitro and in vivo. Among compatible polymers suggested for bone engineering, poly-å-caprolactone(PCL) is receiving considerable attention due to its excellent physical properties, compatibility with tissues, and controlled degradation depending on porosity or copolymerization. In this study, bone marrow was obtained from femurs of New Zealand rabbits, and PCL films were seeded with either whole marrow cells following gradient centrifugation or purified stromal cells after in vitro expansion. To verify the rate of attachment and the type of cell selected by the surface, adhesion/proliferation were measured at 1, 7, 14, 21, and 28 days. Fluorescence and SEM imaging was done at the different time endpoints. This study provides the in vitro evidence that PCL surface is a proper substratum for the attachment and the growth of bone cells. An in vivo implant of PCL scaffolds (2nd part of the study) is the next step to further validate the efficiency of this biodegradable polymer as a scaffold for optimal bone regeneration. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituti Ortopedici Rizzoli, Bologna Università di Catania Università di Napoli Federico II (literal)
Titolo
  • In vitro interactions between rabbit bone marrow precursor cells and PCL surface (literal)
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