Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Monaco L, Passananti C, Fanciulli M. (2003)
  Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb
  in Gene (Amst.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Monaco L, Passananti C, Fanciulli M. (literal)

Pagina inizio

• 57 (literal)

Pagina fine

• 63 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 321 (literal)

Rivista

• Gene (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb (literal)

Abstract

• We recently identified and cloned a novel human gene, Che-1, whose product interacts with both RNA polymerase II and the retinoblastoma gene product (Rb). Furthermore, we found that Che-1 overexpression counteracts the growth inhibitory effects of Rb, regulating in such way both transcription and cell proliferation. In this paper, we describe the genomic organization of the mouse orthologous Che-1 gene and its promoter region. The promoter is TATA less and presents several potential transcription factor-binding motifs. Importantly, we showed that Che-1 expression is regulated by a negative feedback mechanism, in which this protein is present on its own promoter repressing transcription. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR

• CLAUDIO PASSANANTI (Persona)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)

Autore CNR di

• CLAUDIO PASSANANTI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Gene (Rivista)