http://www.cnr.it/ontology/cnr/individuo/prodotto/ID109203

ED and Human target cells (Comunicazione a convegno)

Type

Prodotto della ricerca (Classe)
Comunicazione a convegno (Classe)

Label

ED and Human target cells (Comunicazione a convegno) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Alternative label

Bianchi F.; Maffei S. (2010)
ED and Human target cells
in International Congress - Endocrine Disruptors, Endometriosis and Infertility, Sala delle Conferenze - Piazza
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Bianchi F.; Maffei S. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

In: International Congress - Endocrine Disruptors, Endometriosis and Infertility (Sala delle Conferenze - Piazza Montecitorio - Roma, 08 Aprile 2010). (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

Endocrine disrupting chemicals (EDCs) are compounds in the external environment that mimic or block endogenous hormones they behave as biological signals and, as such, can be misinterpreted by the organism. To date, the vast majority of known EDCs are those that activate the parts of the endocrine system associated with the steroid/retinoid/thyroid super-family of receptors, most often receptors related to the hormone estrogens that are found in all vertebrates. Endocrine-disrupting chemicals (EDCs) in the environment have been linked to human health and disease. Fetal exposure to environmental endocrine disruptors may contribute to the increased incidence of male genital tract malformations, decreased sperm quality, several neoplasms, and altered body weight. Exposure to EDCs early in life can increase risk levels of compromised physical and mental health. Epigenetic mechanisms have been implicated in this process. The ability of an environmental factor (i.e. endocrine disruptor) to promote an epigenetic trans-generational phenotype impacts the potential hazards of environmental toxins, mechanisms of disease, etiology, and evolutionary biology. There are many problems hindering the study of endocrine disruptio (reductionist stance, technically driven research biases, and study of single end points, chemicals and exposure periods). Time exposure may be short or throughout the individual's lifetime. To understand what effect they might have, the individual's social and biological environment, namely its ecology, must be considered. This ecology includes interactions between and within species; for example, symbiotic signaling, predatory- prey interactions, males and females during mating, mother-embryo interactions, and, in mammals, even embryo-embryo interactions. Environmental chemicals with hormone-like activity can disrupt the programming of endocrine signalling pathways that are established during perinatal life and result in adverse consequences that may not be (literal)

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