http://www.cnr.it/ontology/cnr/individuo/prodotto/ID109198

Amyotrophic Lateral Sclerosis: results from Tuscany Registry of Rare Diseases. (Abstract/Poster in atti di convegno)

Type

Abstract/Poster in atti di convegno (Classe)
Prodotto della ricerca (Classe)

Label

Amyotrophic Lateral Sclerosis: results from Tuscany Registry of Rare Diseases. (Abstract/Poster in atti di convegno) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Alternative label

Pierini A.; Minichilli F.; Pieroni F.; Bianchi F. (2010)
Amyotrophic Lateral Sclerosis: results from Tuscany Registry of Rare Diseases.
in Congresso EUROEpi2010, Firenze
(literal)

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Pierini A.; Minichilli F.; Pieroni F.; Bianchi F. (literal)

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In: EUROEpi2010 - Congresso EUROEpi2010 (Firenze, 6-9 novembre 2010). Abstract, vol. 5-6 pp. 114 - 114. International Epidemiological Association (ed.). Epidemiologia & Prevenzione, 2010. (literal)

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Amyotrophic Lateral Sclerosis: results from Tuscany Registry of Rare Diseases. Anna Pierini, Federica Pieroni, Fabrizio Minichilli, Michela Rial and Fabrizio Bianchi Unit of Environmental Epidemiology, Institute of Clinical Physiology-CNR, Pisa Introduction: Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease with an incidence in Europe of approximately 2 per 100,000 per year. As the average disease duration from clinical onset is 3 years, prevalence is estimated at 6 per 100,000. In 90-95% of cases ALS occurs sporadically while 5-10% of cases are familiar. The specific cause of sporadic ALS is unknown while it has been hypothesized that some interactions can occur between genetic, environmental, and age-dependent risk factors. The Tuscany Registry of Rare Diseases (TRRD) was set up in 2005 and involves in data collection all public health centers in Tuscany. The Institute of Clinical Physiology-National Research Council (IFC-CNR) manages the TRRD which is part of the National Network for Rare Diseases leaded by Italian Health Institute. Objectives: To produce knowledge on ALS epidemiology: prevalence/incidence/survival, in Tuscany region. Methods: Age-standardized prevalence and incidence were calculated. Survival analysis was carried out by Kaplan-Meier method. Analysis was performed by Stata v.10. Results: In the period 2005-2009, it comes out in the TRDD are included 282 new patients with definite ALS, 234 of whom resident in Tuscany (122 men-112 women). The standardized average annual incidence in the study period (153 patients, age 20-99) is 0.81/100,000, the highest is 1.15/100,000 in 2006; the highest average incidence rate (2.41/100,000) is amongst patients aged 60-79. On 31 December 2009 (mortality data updated to 2008), the standardized prevalence was 5.36/100,000 (the highest registered is 5.87/100,000 in 2007). Survival rates at 1, 2, 3, 4 and 5 years after the onset were 86%, 70%, 58%, 48% and 44%, respectively. Conclusions: The (literal)

Note