http://www.cnr.it/ontology/cnr/individuo/prodotto/ID109077

The beneficial effects of beta-blockers on ventricular-arterial coupling in idiopathic dilated cardiomyopathy (Abstract in rivista)

Type

Prodotto della ricerca (Classe)
Abstract in rivista (Classe)

Label

The beneficial effects of beta-blockers on ventricular-arterial coupling in idiopathic dilated cardiomyopathy (Abstract in rivista) (literal)

Anno

2007-01-01T00:00:00+01:00 (literal)

Alternative label

Bombardini T.; Gherardi S.; Rigo F.; Pratali L.; Pasanisi E.; Picano E. (2007)
The beneficial effects of beta-blockers on ventricular-arterial coupling in idiopathic dilated cardiomyopathy
in European Journal of Echocardiography, 2007
(literal)

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Bombardini T.; Gherardi S.; Rigo F.; Pratali L.; Pasanisi E.; Picano E. (literal)

Convegno

European Journal of Echocardiography (literal)

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In: European Journal of Echocardiography, vol. December Suppl. Oxford Journals, 2007. (literal)

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Background: Ventricular-arterial coupling is determinant of net cardiovascular performance, altered in dilated cardiomyopathy (DCM). Aim: to assess the effects of beta blocker therapy in DCM at baseline and following dipyridamole stress echo (DIP). Materials and methods: We enrolled 116 consecutive IDC patients (age=60±11 years; 82 males, LVEF = 29±7 %), all referred for DIP. Sixty-seven were on beta-blocker therapy (BB+), and 49 off chronic beta-blocker therapy (BB-). A second group of 117 subjects (age=64±10, EF=62±4 %) underwent stress for routine screening and were the control group. Systolic pressure /end-systolic volume ratio to index LV contractility was determined at rest and peak stress. Effective arterial elastance (EaI) was calculated at rest and peak stress as the ratio of end-systolic pressure (Pes, estimated as systolic pressure x 0.90) by stroke volume, and expressed in the same units as SPESV index=mm Hg/mL/m2. Cardiac output (stroke volume x heart rate) was calculated at baseline and peak stress, and indexed to Body Surface Area. Results: Values at rest and at peak stress are displayed in figure, both for patients on (gray bars) vs off (black bars) beta blockade. When compared to \"normals\", DCM patients showed a marked reduction in left ventricular contractility and increase in arterial elastance, both more pronounced in the Group off-BB and during stress (see figure). Conclusions: DIP significantly optimized ventricular-arterial coupling in controls. In DCM pts, but not in controls, BB maximized DIP induced vasodilator effects with a consequent, greater capability of the heart to increase cardiac output. The effect of BB on peripheral hemodynamics can contribute to its net favorable effect on cardiovascular performance in DCM. (literal)

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