Gender gap in DNA damage due to diagnostic radiation:evidence from children with congenital heart disease (Abstract/Poster in convegno)

Type

• Abstract/Poster in convegno (Classe)
• Prodotto della ricerca (Classe)

Label

• Gender gap in DNA damage due to diagnostic radiation:evidence from children with congenital heart disease (Abstract/Poster in convegno) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Andreassi M. G.; Ait-Ali L.; Manfredi S.; Botto N.; Picano E. (2006)
  Gender gap in DNA damage due to diagnostic radiation:evidence from children with congenital heart disease
  in European Heart Journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Andreassi M. G.; Ait-Ali L.; Manfredi S.; Botto N.; Picano E. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• European Heart Journal, 27 -. Abstract Supplement. European Society of Cardiology, 2006. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Background: According to recent estimates provided by the BEIR (Biological Effects of Ionizing Radiation) VII Committee, the same radiation in the first year of life produces 3 to 4 times the cancer risk as exposure between the ages of 20 and 50. Female infants have almost double the risk as male infants. Direct evaluation of surrogate biological endpoint in exposed children could support these estimations. Aim: to assess the gender-dependent chromosomal damage in patients with congenital heart disease (CHD) and a positive history of diagnostic procedures employing ionising radiation. Methods: We enrolled 34 patients who had undergone ionising testing (with at least one cardiac catheterisation) at 1 year: 17 females (mean age:17.4±9.7 years) and 17 males (mean age:14.7±9.7 years). A control group of 32 healthy subjects consisting of 17 males (age:16.1±12.3 years ) and 15 females (12.1±10.5 years) was also included. Micronucleus assay (MN) in peripheral blood lymphocytes was used as a sensitive biomarker of chromosomal damage and intermediate endpoint in carcinogenesis. Results: MN levels were higher in patients when compared to healthy controls. Female patients had higher levels of MN than male patients, whereas no gender difference was found in age-matched controls. Female and male patients were comparable for age (p (literal)

Titolo

• Gender gap in DNA damage due to diagnostic radiation:evidence from children with congenital heart disease (literal)

Prodotto di

• Institute of clinical physiology (IFC) (Istituto)
• Ricerca Cardiopolmonare (ME.P01.004.001) (Modulo)

Autore CNR

• EUGENIO PICANO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Gender gap in DNA damage due to diagnostic radiation:evidence from children with congenital heart disease" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• EUGENIO PICANO (Unità di personale interno)

Prodotto

• Institute of clinical physiology (IFC) (Istituto)
• Ricerca Cardiopolmonare (ME.P01.004.001) (Modulo)

Insieme di parole chiave di

• Parole chiave di "Gender gap in DNA damage due to diagnostic radiation:evidence from children with congenital heart disease" (Insieme di parole chiave)