Protein modulation in mouse heart under acute and chronic hypoxia. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Protein modulation in mouse heart under acute and chronic hypoxia. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Viganò A. 1, Vasso M. 1,2, Caretti A. 3, Bravatà V. 2,4, Terraneo L. 3, Fania C. 1, Capitanio D. 1, Samaja M. 3, Gelfi C. 1,2 (2011)
  Protein modulation in mouse heart under acute and chronic hypoxia.
  in Proteomics (Weinh., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Viganò A. 1, Vasso M. 1,2, Caretti A. 3, Bravatà V. 2,4, Terraneo L. 3, Fania C. 1, Capitanio D. 1, Samaja M. 3, Gelfi C. 1,2 (literal)

Pagina inizio

• 4202 (literal)

Pagina fine

• 4217 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Proteomics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Pubblicato on-line: 24 Settembre 2011. Corresponding author: C. Gelfi (cecilia.gelfi@unimi.it) IF 2010: 4.815 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Milano, Segrate (MI). 2. CNR-IBFM Segrate (MI). 3. Dipartimento di Medicina, Chirurgia e Odontoiatria, Ospedale San Paolo, Università degli Studi, Milano. 4. LATO, HSR Giglio, Cefalù (PA). (literal)

Titolo

• Protein modulation in mouse heart under acute and chronic hypoxia. (literal)

Abstract

• Exploring cellular mechanisms underlying beneficial and detrimental responses to hypoxia represents the object of the present study. Signaling molecules controlling adaptation to hypoxia (HIF-1±), energy balance (AMPK), mitochondrial biogenesis (PGC-1±), autophagic/apoptotic processes regulation and proteomic dysregulation were assessed. Responses to acute hypoxia (AH) and chronic hypoxia (CH) in mouse heart proteome were detected by 2-D DIGE, mass spectrometry and antigen-antibody reactions. Both in AH and CH, the results indicated a deregulation of proteins related to sarcomere stabilization and muscle contraction. Neither in AH nor in CH the HIF-1± stabilization was observed. In AH, the metabolic adaptation to lack of oxygen was controlled by AMPK activation and sustained by an up-regulation of adenosylhomocysteinase and acetyl-CoA synthetase. AH was characterized by the mitophagic protein Bnip 3 increment. PGC-1±, a master regulator of mitochondrial biogenesis, was down-regulated. CH was characterized by the up-regulation of enzymes involved in antioxidant defense, in aldehyde bio-product detoxification and in misfolded protein degradation. In addition, a general down-regulation of enzymes controlling anaerobic metabolism was observed. After 10 days of hypoxia, cardioprotective molecules were substantially decreased whereas pro-apoptotic molecules increased accompained by down-regulation of specific target proteins. (literal)

Prodotto di

• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• MICHELE VASSO (Persona)
• CECILIA GELFI (Unità di personale esterno)
• Valentina Bravatà (Persona)

Insieme di parole chiave

• Keywords of "Protein modulation in mouse heart under acute and chronic hypoxia." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)

Autore CNR di

• MICHELE VASSO (Persona)
• Valentina Bravatà (Persona)
• CECILIA GELFI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Proteomics (Rivista)

Insieme di parole chiave di

• Keywords of "Protein modulation in mouse heart under acute and chronic hypoxia." (Insieme di parole chiave)