Functional impairment of skeletal muscle oxidative metabolism during knee-extension exercise after bed rest. (Articolo in rivista)

Type
Label
  • Functional impairment of skeletal muscle oxidative metabolism during knee-extension exercise after bed rest. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Salvadego D. 1, Lazzer S. 1, Marzorati M. 2, Porcelli S. 2,3, Rejc E. 1, Simunic B. 4, Pisot R. 4, di Prampero P.E. 1, Grassi B. 1 (2011)
    Functional impairment of skeletal muscle oxidative metabolism during knee-extension exercise after bed rest.
    in Journal of applied physiology (1985)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Salvadego D. 1, Lazzer S. 1, Marzorati M. 2, Porcelli S. 2,3, Rejc E. 1, Simunic B. 4, Pisot R. 4, di Prampero P.E. 1, Grassi B. 1 (literal)
Pagina inizio
  • 1719 (literal)
Pagina fine
  • 1726 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 111 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Pubblicato on-line: 15 Settembre 2011. Corresponding author: B. Grassi (bruno.grassi@uniud.it) IF 2010: 4.232 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Department of Medical and Biological Sciences, University of Udine, Udine. 2. Institute of Bioimaging and Molecular Physiology, CNR, Segrate (MI) 3. Faculty of Scienze Motorie, Uni-tel San Raffaele, Roma. 4. Institute of Kinesiology Research, University of Primorska, Koper (Slovenia) (literal)
Titolo
  • Functional impairment of skeletal muscle oxidative metabolism during knee-extension exercise after bed rest. (literal)
Abstract
  • A functional evaluation of skeletal muscle oxidative metabolism during dynamic knee-extension (KE) incremental exercises was carried out following a 35-day bed rest (BR) (Valdoltra 2008 BR campaign). Nine young male volunteers (age: 23.5 ± 2.2 years [mean ± SD]) were evaluated. Pulmonary gas exchange, heart rate (HR) and cardiac output (Q, by impedance cardiography), skeletal muscle (vastus lateralis) fractional O(2) extraction and brain (frontal cortex) oxygenation (by near-infrared spectroscopy) were determined during incremental KE. Values at exhaustion were considered \"peak\". Peak HR (147 ± 18 beats(.)min(-1) before vs. 146 ± 17 after BR) and peak (17.8 ± 3.3 L(.)min(-1) before vs. 16.1 ± 1.8 after BR) were unaffected by BR. As expected, brain oxygenation did not decrease during KE. Peak O(2) uptake (VO (2)peak) was lower after vs. before BR, both when expressed as L(.)min(-1) (0.99 ± 0.17 vs. 1.26 ± 0.27) and when normalized per unit of quadriceps muscle mass (46.5 ± 6.4 mL(.)min(-1)(.)100g(-1) vs. 56.9 ± 11.0). Skeletal muscle peak fractional O(2) extraction, expressed as a percentage of the maximal values obtained during a transient limb ischemia, was lower after (46.3 ± 12.1%) vs. before BR (66.5 ± 11.2). After eliminating, by the adopted exercise protocol, constraints related to cardiovascular O(2) delivery, a decrease in VO (2)peak and muscle peak capacity of fractional O(2) extraction was found after 35 days of BR. These findings suggest a substantial impairment of oxidative function at the muscle level, \"downstream\" with respect to bulk blood flow to the exercising muscles, that is possibly at the level of blood flow distribution/O(2) utilization inside the muscle, peripheral O(2) diffusion, intracellular oxidative metabolism. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it