Diversity of human skeletal muscle in health and disease: Contribution of proteomics. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Diversity of human skeletal muscle in health and disease: Contribution of proteomics. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Gelfi C. 1,2, Vasso M. 1,2, Cerretelli P. 2 (2011)
  Diversity of human skeletal muscle in health and disease: Contribution of proteomics.
  
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gelfi C. 1,2, Vasso M. 1,2, Cerretelli P. 2 (literal)

Pagina inizio

• 774 (literal)

Pagina fine

• 795 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 74 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Pubblicato on-line: 14 Marzo 2011 Corresponding author: C. Gelfi (cecilia.gelfi@unimi.it) IF 2010: 5.074 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Milano. 2. Istituto di Bioimmagini e Fisiologia Molecolare, C.N.R., Segrate (MI) (literal)

Titolo

• Diversity of human skeletal muscle in health and disease: Contribution of proteomics. (literal)

Abstract

• Muscle represents a large fraction of the human body mass. It is an extremely heterogeneous tissue featuring in its contractile structure various proportions of heavy- and light-chain slow type 1 and fast type 2A and 2X myosins, actins, tropomyosins, and troponin complexes as well as metabolic proteins (enzymes and most of the players of the so-called excitation-transcription coupling). Muscle is characterized by wide plasticity, i.e. capacity to adjust size and functional properties in response to endogenous and exogenous influences. Over the last decade, proteomics has become a crucial technique for the assessment of muscle at the molecular level and the investigation of its functional changes. Advantages and shortcomings of recent techniques for muscle proteome analysis are discussed. Data from differential proteomics applied to healthy individuals in normal and unusual environments (hypoxia, cold), in exercise, immobilization, ageing and to patients with neuromuscular hereditary disorders (NMD's), inclusion bodies myositis and insulin resistance are summarized, critically discussed and, when required, compared with homologous data from pertinent animal models. The advantages as well as the limits of proteomics in view of the identification of new biomarkers are evaluated. (literal)

Prodotto di

• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• CECILIA GELFI (Unità di personale esterno)
• MICHELE VASSO (Persona)
• PAOLO CERRETELLI (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "Diversity of human skeletal muscle in health and disease: Contribution of proteomics." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)

Autore CNR di

• PAOLO CERRETELLI (Unità di personale esterno)
• MICHELE VASSO (Persona)
• CECILIA GELFI (Unità di personale esterno)

Insieme di parole chiave di

• Parole chiave di "Diversity of human skeletal muscle in health and disease: Contribution of proteomics." (Insieme di parole chiave)