Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Moriggi M. 1, Vasso M. 1,2, Fania C.1, Capitanio D. 1, Bonifacio G. 1,2, Salanova M. 3, Blottner D. 3, Rittweger J. 4, Felsenberg D. 5, Cerretelli P. 6, Gelfi C. 1,6 (2010)
  Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation.
  in Proteomics (Weinh., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Moriggi M. 1, Vasso M. 1,2, Fania C.1, Capitanio D. 1, Bonifacio G. 1,2, Salanova M. 3, Blottner D. 3, Rittweger J. 4, Felsenberg D. 5, Cerretelli P. 6, Gelfi C. 1,6 (literal)

Pagina inizio

• 3756 (literal)

Pagina fine

• 3774 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 10 (literal)

Rivista

• Proteomics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Pubblicato on-line: 23 Agosto 2010. Corresponding author: C. Gelfi (cecilia.gelfi@unimi.it) IF 2010: 4.815 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Dipartimento di Scienze e Tecnologie Biomediche, Università degli Studi di Milano, Milano. 2. LATO-HSR Giglio, Cefalù (PA). 3. Charité-Universitats Medizin Berlin, Campus Benjamin Franklin, Vegetative Anatomy and Zentrum fur Weltraummedizin, Berlin (Germania) 4. Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Manchester (GB) 5 Charité-Universitats Medizin Berlin, Campus Benjamin Franklin, Zentrum fur Muskel und Knochenforschung, Berlin (Germania) 6. CNR-Istituto di Bioimmagini e Fisiologia Molecolare, Milano. (literal)

Titolo

• Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation. (literal)

Abstract

• The present investigation, the first in the field, was aimed at analyzing differentially, on individual samples, the effects of 55 days of horizontal bed rest, a model for microgravity, on myosin heavy and myosin light chain isoforms distribution (by SDS) and on the proteome (by 2-D DIGE and MS) in the vastus lateralis (VL), a mixed type II/I (<50:50%) head of the quadriceps and in the calf soleus (SOL), a predominantly slow (<35:65%) twitch muscle. Two separate studies were performed on six subjects without (BR) and six with resistive vibration exercise (RVE) countermeasures, respectively. Both VL and SOL underwent in BR decrements of <15% in cross-sectional area and of <22% in maximal torque that were prevented by RVE. Myosin heavy chain distribution showed increased type I and decreased type IIA in BR both in VL and in SOL, the opposite with RVE. A substantial downregulation of proteins involved in aerobic metabolism characterized both in SOL and VL in BR. RVE reversed the pattern more in VL than in SOL, whereas proteins involved in anaerobic glycolysis were upregulated. Proteins from the Z-disk region and from costamers were differently dysregulated during bed rest (both BR and RVE), particularly in VL. (literal)

Prodotto di

• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• PAOLO CERRETELLI (Unità di personale esterno)
• CECILIA GELFI (Unità di personale esterno)
• MICHELE VASSO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)

Autore CNR di

• PAOLO CERRETELLI (Unità di personale esterno)
• MICHELE VASSO (Unità di personale interno)
• CECILIA GELFI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Proteomics (Rivista)

Insieme di parole chiave di

• Keywords of "Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation." (Insieme di parole chiave)