Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging. (Articolo in rivista)

Type
Label
  • Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Marini C. 1, Giusti M. 2, Armonino R. 3, Ghigliotti G. 4, Bezante G. 4, Vera L. 2, Morbelli S. 3, Pomposelli E. 3, Massollo M. 3, Gandolfo P. 3, Minuto F. 2, Sambuceti G. 3 (2010)
    Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging.
    in European journal of nuclear medicine and molecular imaging (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Marini C. 1, Giusti M. 2, Armonino R. 3, Ghigliotti G. 4, Bezante G. 4, Vera L. 2, Morbelli S. 3, Pomposelli E. 3, Massollo M. 3, Gandolfo P. 3, Minuto F. 2, Sambuceti G. 3 (literal)
Pagina inizio
  • 2256 (literal)
Pagina fine
  • 2263 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 37 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Pubblicato on-line: 4 Settembre 2010. Corresponding author: C. Marini (cecilia.marini@unige.it) IF 2010: 5.036 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. CNR-Institute of Bioimages and Molecular Physiology, Genova Section, Genova. 2. Endocrinology, Department of Endocrinological and Metabolic Sciences, University of Genova, Genova. 3. Nuclear Medicine, Department of Internal Medicine, University of Genova, Genova. 4. Cardiology, Department of Internal Medicine, University of Genova, Genova. (literal)
Titolo
  • Reduced coronary flow reserve in patients with primary hyperparathyroidism: a study by G-SPECT myocardial perfusion imaging. (literal)
Abstract
  • PURPOSE: The mechanisms underlying increased cardiovascular risk in primary hyperparathyroidism (pHPT) have not been fully defined. Recently, this issue has become the subject of renewed interest due to the increasing evidence that the endothelium and vascular wall are targets for parathyroid hormone (PTH). The aim of this study was to measure regional coronary flow reserve (CFR) to determine whether the vascular damage induced by pHPT extends to affect the coronary microvascular function. METHODS: A total of 22 pHPT patients without a history of coronary artery disease and 7 age-matched control subjects were recruited. Dipyridamole myocardial blood flow (MBF) was assessed using (99m)Tc-sestamibi by measuring first-transit counts in the pulmonary artery and myocardial count rate from G-SPECT images. Baseline MBF was estimated 2 h later according to the same procedure. Regional CFR was defined as the ratio between dipyridamole and baseline MBF using a 17-segment left ventricular model. RESULTS: Three pHPT patients showed reversible perfusion defects and were excluded from the analysis. In the remaining 19, CFR was significantly lower with respect to the control subjects (1.88 +/- 0.64 vs. 3.36 +/- 0.66, respectively; p < 0.01). Moreover, patients studied for more than 28 months from pHPT diagnosis showed lower CFR values than the others (1.42 +/- 0.18 vs. 2.25 +/- 0.64, respectively; p < 0.01). Consequently, the time from diagnosis to the nuclear study showed a reasonable correlation with the degree of CFR impairment (Spearman's rho -0.667, p < 0.02). CONCLUSION: pHPT is associated with a significant dysfunction of the coronary microcirculation. This disorder might contribute to the high cardiovascular risk of conditions characterized by chronic elevations in serum PTH levels. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it